PMID: 6397370Jan 1, 1984Paper

Structural and genetic relationships between cytosolic and mitochondrial isoenzymes

The International Journal of Biochemistry
S DoonanF Bossa

Abstract

The most common type of genetic relationship between cytosolic and mitochondrial isoenzymes will probably be found to be divergent evolution from a common ancestral form. This is firmly established for the aspartate aminotransferases and less directly so in other cases. The two isoenzymes of aspartate aminotransferase have evolved at roughly equal rates at the level of total amino acid sequence but certain limited surface regions of the mitochondrial form have been much more highly conserved than corresponding regions in the cytosolic protein; these regions probably play a role in topogenesis of the mitochondrial isoenzyme. It is of interest that nearly all mitochondrial proteins are initially synthesised as precursors of molecular weight greater than the mature forms. In the case of aspartate aminotransferase, and possibly of other such isoenzymes, the N-terminus of the mature protein is nearly coincident with that of the cytosolic isoenzyme. Hence during evolution either the gene for the mitochondrial isoenzyme has gained an extra coding region for this N-terminal extension or, less likely, the structural gene for the cytosolic form has suffered a sizeable terminal deletion. Cytosolic and mitochondrial superoxide dismutases h...Continue Reading

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Citations

Feb 1, 1988·Biochemical Genetics·L R Munneke, G E Collier
Feb 3, 2011·Journal of Bioenergetics and Biomembranes·R A P CostaN C Souza-Pinto
Jan 1, 1985·The International Journal of Biochemistry·D F DonnellyS Doonan
Jan 1, 1988·The International Journal of Biochemistry·D Boonyarat, S Doonan
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S R EllisN C Martin
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·S Müller, H J Seitz
Oct 7, 2016·Cell Biochemistry and Biophysics·Christopher Prescott, Steven E Bottle
Oct 1, 1986·Bioscience Reports·B T Kinsella, S Doonan
Sep 25, 2020·Journal of Biomolecular Structure & Dynamics·Venkatasubramanian HemagowriKirankumar Santhakumar
Nov 8, 1985·Biochimica Et Biophysica Acta·F MartiniF Bossa

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