Structural and Mechanical Comparison of Human Ear, Alar, and Septal Cartilage

Plastic and Reconstructive Surgery. Global Open
Ernst Jan BosPaul P van Zuijlen

Abstract

In the human ear and nose, cartilage plays a key role in establishing its form and function. Interestingly, there is a noticeable paucity on biochemical, structural, and mechanical studies focused on facial cartilage. Such studies are needed to provide elementary knowledge that is fundamental to tissue engineering of cartilage. Therefore, in this study, a comparison is made of the biochemical, structural, and mechanical differences between ear, ala nasi, and septum on the extracellular matrix (ECM) level. Cartilage samples were harvested from 10 cadaveric donors. Each sample was indented 10 times with a nanoindenter to determine the effective Young's modulus. Structural information of the cartilage was obtained by multiple-photon laser scanning microscopy capable of revealing matrix components at subcellular resolution. Biochemistry was performed to measure glycosaminoglycan (GAG), DNA, elastin, and collagen content. Significant differences were seen in stiffness between ear and septal cartilage (P= 0.011) and between ala nasi and septal cartilage (P= 0.005). Elastin content was significantly higher in ear cartilage. Per cartilage subtype, effective Young's modulus was not significantly correlated with cell density, GAG, or col...Continue Reading

References

Jun 25, 1998·Archives of Otolaryngology--head & Neck Surgery·J C Britt, S S Park
Jan 9, 1999·Burns : Journal of the International Society for Burn Injuries·P S Bhandari
May 23, 2001·Archives of Facial Plastic Surgery·B P DriscollB P Drisco
Jul 23, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Andreas NaumannArnold I Caplan
Feb 27, 2004·Journal of Biomedical Materials Research. Part a·Rani RoyLawrence J Bonassar
Jul 20, 2007·Archives of Facial Plastic Surgery·Richard W WestreichWilliam Lawson
Nov 22, 2008·Journal of Biomedical Optics·Jessica C MansfieldSteve J Matcher
Jan 21, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Hirohisa KusuharaWilliam J Landis
Jul 3, 2009·Cell Stem Cell·Farshid GuilakChristopher S Chen
Nov 18, 2009·Archives of Facial Plastic Surgery·Russell W H KridelCarol G Hart
Jul 9, 2010·The Journal of Craniofacial Surgery·Edward RayMark M Urata
Dec 7, 2010·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Yang Qing-HuaZhuang Hong-Xing
Feb 10, 2011·Tissue Engineering. Part B, Reviews·Clayton T McKeeChristopher J Murphy
Mar 17, 2011·Tissue Engineering. Part B, Reviews·Christopher James LittleXiongbiao Chen
Aug 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Shinji KobayashiHideki Taniguchi
Aug 14, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Pauline D VerhaegenPaul P van Zuijlen
Dec 5, 2012·The Review of Scientific Instruments·D ChavanD Iannuzzi
Apr 10, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Johannah Sanchez-AdamsFarshid Guilak
May 18, 2013·Tissue Engineering. Part B, Reviews·Luc NimeskernKathryn S Stok
Aug 27, 2013·Osteoarthritis and Cartilage·X ZhuJ Chen
Aug 1, 2015·Journal of Anatomy·Neal Anthwal, Hannah Thompson
Dec 18, 2015·Journal of Materials Science. Materials in Medicine·M F GriffinP E M Butler
Jan 17, 2016·Journal of Biomechanics·Luc NimeskernKathryn S Stok
Feb 18, 2017·Journal of Functional Biomaterials·Marica MarreseLuigi Ambrosio

❮ Previous
Next ❯

Citations

Jan 16, 2020·Polymers·Aureliano FertuzinhosNuno Dourado
Dec 14, 2019·Current Stem Cell Research & Therapy·Zohreh BagherAlexander Seifalian
Jun 23, 2020·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Kelly A A KwaBouke K H L Boekema
Aug 31, 2020·Laryngoscope Investigative Otolaryngology·Weston L NiermeyerTendy Chiang
Dec 15, 2020·Tissue Engineering. Part B, Reviews·Anna TrengoveAndrea J O'Connor
Jun 23, 2020·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Thomas H JovicIain S Whitaker
May 9, 2021·Biochemical and Biophysical Research Communications·Rajiv S RaktoeAbdoelwaheb El Ghalbzouri
May 18, 2021·Nature Reviews. Materials·Benjamin J BielajewKyriacos A Athanasiou
May 31, 2021·International Journal of Biological Macromolecules·Yuzhou YangZhimin Zhou
Jul 28, 2021·Aesthetic Plastic Surgery·Yanyan CaoYonghuan Zhen
Oct 24, 2021·Journal of Tissue Engineering and Regenerative Medicine·Eva Goldberg-BockhornNicole Rotter
Nov 23, 2021·Frontiers in Bioengineering and Biotechnology·Rory Gibney, Eleonora Ferraris

❮ Previous
Next ❯

Methods Mentioned

BETA
atomic force microscopy
AFM
biopsy
Assay

Software Mentioned

SPSS Statistics
TriMScope I
Imspector Pro
ImageJ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.