Structural and Mechanistic Features of ClyA-Like α-Pore-Forming Toxins

Toxins
Bastian Bräuning, Michael Groll

Abstract

Recent technological advances have seen increasing numbers of complex structures from diverse pore-forming toxins (PFT). The ClyA family of α-PFTs comprises a broad variety of assemblies including single-, two- and three-component toxin systems. With crystal structures available for soluble subunits of all major groups in this extended protein family, efforts now focus on obtaining molecular insights into physiological pore formation. This review provides an up-to-date discussion on common and divergent structural and functional traits that distinguish the various ClyA family PFTs. Open questions of this research topic are outlined and discussed.

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Citations

Feb 13, 2021·Toxins·Yajuan LiTengchuan Jin
Dec 10, 2020·Accounts of Chemical Research·Pradeep SathyanarayanaK Ganapathy Ayappa
Sep 22, 2020·The Journal of Membrane Biology·Anish Kumar MondalKausik Chattopadhyay

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Methods Mentioned

BETA
X-ray
dissection

Software Mentioned

MAC

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