May 14, 2011

Structural and mechanistic investigations of photosystem II through computational methods

Biochimica Et Biophysica Acta
Felix M Ho

Abstract

The advent of oxygenic photosynthesis through water oxidation by photosystem II (PSII) transformed the planet, ultimately allowing the evolution of aerobic respiration and an explosion of ecological diversity. The importance of this enzyme to life on Earth has ironically been paralleled by the elusiveness of a detailed understanding of its precise catalytic mechanism. Computational investigations have in recent years provided more and more insights into the structural and mechanistic details that underlie the workings of PSII. This review will present an overview of some of these studies, focusing on those that have aimed at elucidating the mechanism of water oxidation at the CaMn₄ cluster in PSII, and those exploring the features of the structure and dynamics of this enzyme that enable it to catalyse this energetically demanding reaction. This article is part of a Special Issue entitled: Photosystem II.

  • References79
  • Citations15

References

  • References79
  • Citations15

Citations

Mentioned in this Paper

Plastoquinol
Biochemical Pathway
Fluctuation
Cytochrome C Oxidase
Energy Transfer
Thylakoid Membrane
Hyrex Brand of Dimenhydrinate
Entire Lumen of Body System
Diuron
Complex (molecular entity)

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