PMID: 6402562Mar 1, 1983Paper

Structural and metabolic relationships between goldfish brain glycoproteins participating in functional plasticity of the central nervous system

Journal of Neurochemistry
R Schmidt, V E Shashoua

Abstract

Ependymins beta and gamma (MW 32,000 and 26,000 daltons) are two secreted goldfish brain glycoproteins that exhibit a specifically enhanced turnover rate when the animals successfully acquire a new pattern of swimming behaviour. Both proteins are bound identically to concanavalin A and can be isolated from brain extracellular fluid and from brain cytoplasm by lectin affinity chromatography. Radioimmunoassay data, using purified 125I-labeled ependymins and antisera directed against ependymin beta or ependymin gamma, show complete cross-reactivity between the two proteins. It is demonstrated by Scatchard-plot analysis that the antisera recognize identical immunological determinants in both proteins. The amino acid composition of the ependymins is similar, and several identical polypeptide fragments are obtained after limited proteolysis with Staphylococcus aureus protease. The proteins are capable of forming complexes of the compositions gamma 2, beta gamma, and beta 2. A protease present in the extracellular fluid of goldfish brain promotes proteolysis of ependymin beta to ependymin gamma. The finding that ependymin gamma is physiologically derived from ependymin beta suggests the possibility that ependymin beta might exert its ...Continue Reading

References

Dec 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J Houmard, G R Drapeau
Feb 1, 1962·The Journal of Clinical Investigation·R D UTIGERW H DAUGHADAY

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Citations

Jan 1, 1991·Journal of Neurobiology·J T SchmidtC A Stuermer
Jun 1, 1985·Cellular and Molecular Neurobiology·V E Shashoua
Jan 1, 1987·Neurochemistry International·R Schmidt, H Lapp
Jan 1, 1985·Progress in Neurobiology·H J Markowitsch, M Pritzel
Jul 31, 1986·Biochemical and Biophysical Research Communications·V E ShashouaF B Jungalwala
Jan 1, 1991·Annals of the New York Academy of Sciences·V E Shashoua
Apr 1, 1987·Journal of Neuroimmunology·R LappukeP F Bartlett
Mar 27, 2009·Proteomics·Richard W SmithGöran E Nilsson
Sep 1, 1992·Experimental Neurology·F R ThormodssonB Grafstein
Dec 1, 1992·Experimental Neurology·F R ThormodssonB Grafstein
Jun 1, 1987·Journal of Neurochemistry·R Schmidt, H Lapp
Jan 1, 1989·Journal of Neurochemistry·A KönigstorferW Hoffmann
Nov 1, 1994·Neurochemical Research·S F LakosB Grafstein

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