Structural and numerical chromosome aberration inducers in liver micronucleus test in rats with partial hepatectomy

Mutation Research
Satoru ItohAtsushi Sanbuissho

Abstract

The liver micronucleus test is an important method to detect pro-mutagens such as active metabolites not reaching bone marrow due to their short lifespan. We have already reported that dosing of the test compound after partial hepatectomy (PH) is essential to detect genotoxicity of numerical chromosome aberration inducers in mice [Mutat. Res. 632 (2007) 89-98]. In naive animals, the proportion of binucleated cells in rats is less than half of that in mice, which suggests a species difference in the response to chromosome aberration inducers. In the present study, we investigated the responses to structural and numerical chromosome aberration inducers in the rat liver micronucleus test. Two structural chromosome aberretion inducers (diethylnitrosamine and 1,2-dimethylhydrazine) and two numerical chromosome aberration inducers (colchicine and carbendazim) were used in the present study. PH was performed a day before or after the dosing of the test compound in 8-week old male F344 rats and hepatocytes were isolated 4 days after the PH. As a result, diethylnitrosamine and 1,2-dimethylhydrazine, structural chromosome aberration inducers, exhibited significant increase in the incidence of micronucleated hepatocyte (MNH) when given ei...Continue Reading

References

Jun 13, 1997·Mutation Research·M Igarashi, H Shimada
Oct 21, 1998·The Journal of Toxicological Sciences·C HamadaI Yoshimura
Jul 11, 2002·Mutation Research·Micheline Kirsch-VoldersIlse Decordier
Dec 9, 2010·The Journal of Toxicological Sciences·Miyuki IgarashiShuji Tsuda

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Citations

Sep 18, 2012·Toxicology Letters·Satoru ItohWataru Takasaki
May 9, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Yoshifumi UnoHironao Takasawa
Apr 14, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Satoru ItohChiharu Hattori
Nov 21, 2019·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Xiaoqing GuoNan Mei

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