Structural and Surface Compatibility Study of Modified Electrospun Poly(ε-caprolactone) (PCL) Composites for Skin Tissue Engineering

AAPS PharmSciTech
Kajal GhosalSabu Thomas

Abstract

In this study, biodegradable poly(ε-caprolactone) (PCL) nanofibers (PCL-NF), collagen-coated PCL nanofibers (Col-c-PCL), and titanium dioxide-incorporated PCL (TiO2-i-PCL) nanofibers were prepared by electrospinning technique to study the surface and structural compatibility of these scaffolds for skin tisuue engineering. Collagen coating over the PCL nanofibers was done by electrospinning process. Morphology of PCL nanofibers in electrospinning was investigated at different voltages and at different concentrations of PCL. The morphology, interaction between different materials, surface property, and presence of TiO2 were studied by scanning electron microscopy (SEM), Fourier transform IR spectroscopy (FTIR), contact angle measurement, energy dispersion X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS). MTT assay and cell adhesion study were done to check biocompatibilty of these scaffolds. SEM study confirmed the formation of nanofibers without beads. FTIR proved presence of collagen on PCL scaffold, and contact angle study showed increment of hydrophilicity of Col-c-PCL and TiO2-i-PCL due to collagen coating and incorporation of TiO2, respectively. EDX and XPS studies revealed distribution of entrapped TiO2...Continue Reading

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Citations

Apr 13, 2017·Journal of Biomaterials Science. Polymer Edition·Qin ZouYubao Li
Mar 24, 2018·Scientific Reports·Kajal GhosalIvo Provaznik
May 16, 2018·Molecular Biotechnology·Nadeem SiddiquiSreenivasa Rao
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Feb 14, 2019·AAPS PharmSciTech·Aishwarya Satish, Purna Sai Korrapati
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Methods Mentioned

BETA
X-ray
ELISA
Assay
Fluorescence

Software Mentioned

FT
PerkinElmer
Digimizer®
IR
MS Excel
Aztec
XPS MultiQuant

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