Structural aspects of nucleic acid-sensing Toll-like receptors

Biophysics Reviews
Umeharu Ohto, Toshiyuki Shimizu

Abstract

Invading pathogens elicit potent immune responses in cells through interactions between structurally conserved molecules derived from the pathogens and specialized innate immune receptors such as the Toll-like receptors (TLRs). Nucleic acid is one of the principal TLR ligands. Nucleic acid-sensing TLRs recognize an array of nucleic acids, including double-stranded RNA, single-stranded RNA, and DNAs with specific sequence motifs. Although ligand-induced dimerization is commonly observed followed by TLR activation, both the specific recognition mechanisms and the ligand-receptor interactions vary among different TLRs. In this review, we highlight our current understanding of how these receptors recognize their cognate ligands based on the recent advances in structural biology.

References

Apr 6, 1995·Nature·A M KriegD M Klinman
Dec 29, 2000·Nature·H HemmiS Akira
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·S BauerG B Lipford
May 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jongdae LeeHoward B Cottam
Oct 14, 2003·Trends in Immunology·Jessica K BellDavid M Segal
Feb 21, 2004·Science·Sandra S DieboldCaetano Reis e Sousa
Mar 23, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer M LundRichard A Flavell
Aug 13, 2004·European Journal of Immunology·Mark RutzStefan Bauer
Jun 18, 2005·Science·Jungwoo ChoeIan A Wilson
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jared C RoachAlan Aderem
Jul 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jessica K BellDavid R Davies
May 16, 2006·Journal of Leukocyte Biology·Sinead M Miggin, Luke A J O'Neill
Jan 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Joshua N LeonardDavid M Segal
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mirjam E PeterAlexander H Dalpke
Sep 24, 2010·The Journal of Biological Chemistry·Yan WangDavid M Segal
Sep 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jack A DunkleJamie H D Cate
Dec 7, 2010·The Journal of Biological Chemistry·Zhongcheng ShiDekai Zhang
Jan 12, 2011·Annual Review of Immunology·Roman BarbalatGregory M Barton
Feb 22, 2012·Science·Sung-il YoonIan A Wilson
May 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Alejandra Garcia-CattaneoPhilippe Benaroch
Aug 7, 2012·The Journal of Biological Chemistry·Rongsu QiC Cheng Kao
Aug 24, 2012·PLoS Pathogens·Sophia MaschalidiBénédicte Manoury
Oct 11, 2012·Immunological Reviews·Dong Hyun Song, Jie-Oh Lee
Oct 23, 2012·Cellular & Molecular Immunology·Jorge L CervantesJuan C Salazar
Oct 31, 2012·ELife·Xiao-Dong Li, Zhijian James Chen
Feb 13, 2013·Nature Reviews. Genetics·Zachary D Smith, Alexander Meissner
Jun 12, 2013·Nature Communications·Masahiro OnjiKensuke Miyake
Jan 30, 2014·ChemMedChem·Hari Prasad KokatlaSunil A David
Jan 20, 2015·Nature Structural & Molecular Biology·Hiromi TanjiToshiyuki Shimizu
Jan 21, 2015·Nature Communications·Mei Po ChanKensuke Miyake

❮ Previous
Next ❯

Citations

Jan 9, 2019·Frontiers in Immunology·D Channe Gowda, Xianzhu Wu
May 17, 2017·Biophysics Reviews·Cris Dos Remedios
Dec 22, 2020·Frontiers in Cellular and Infection Microbiology·Xiao HeXin-Zhuan Su
Aug 12, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Senny NordmeierVictoria Portnoy
Dec 18, 2020·Frontiers in Immunology·Ayesha ZahidTengchuan Jin
Jul 2, 2021·Journal of Immunology Research·Payam BehzadiTomasz M Karpiński

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Trends in Cell Biology
Bettina L Lee, Gregory M Barton
Archivum Immunologiae Et Therapiae Experimentalis
Catherine M Greene, Noel G McElvaney
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Vijayakumar GosuSangdun Choi
© 2022 Meta ULC. All rights reserved