Structural asymmetry of the human cerebral cortex: Regional and between-subject variability of surface area, cortical thickness, and local gyrification

Neuropsychologia
Christine ChiarelloAlessandra McDowell

Abstract

Structural asymmetry varies across individuals, brain regions, and metrics of cortical organization. The current study investigated regional differences in asymmetry of cortical surface area, thickness, and local gyrification, and the extent of between-subject variability in these metrics, in a sample of healthy young adults (N=200). Between-subject variability in cortical structure may provide a means to assess the extent of biological flexibility or constraint of brain regions, and we explored the potential influence of this variability on the phenotypic expression of structural asymmetry. The findings demonstrate that structural asymmetries are nearly ubiquitous across the cortex, with differing regional organization for the three cortical metrics. This implies that there are multiple, only partially overlapping, maps of structural asymmetry. The results further indicate that the degree of asymmetry of a brain region can be predicted by the extent of the region's between-subject variability. These findings provide evidence that reduced biological constraint promotes the expression of strong structural asymmetry.

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Citations

Nov 2, 2016·Cerebral Cortex·Nickie N AndescavageCatherine Limperopoulos
May 17, 2018·Proceedings of the National Academy of Sciences of the United States of America·Xiang-Zhen KongClyde Francks
Apr 22, 2020·Proceedings. Biological Sciences·Alex R DeCasienJames P Higham
Jun 30, 2018·Bipolar Disorders·Rachel Hb MitchellBenjamin I Goldstein
Sep 12, 2018·Journal of Experimental Neuroscience·Hong XieXin Wang
Nov 13, 2018·Laterality·Meredith ScheppeleTimothy T Brown
Feb 7, 2020·Neuroscience·M EstevesH Leite-Almeida
Dec 15, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Alvand HassankhaniSeyed Ali Nabavizadeh
Mar 20, 2021·Brain Structure & Function·Patrizia Bisiacchi, Elisa Cainelli

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