Structural atlas of dynein motors at atomic resolution

Biophysics Reviews
Akiyuki TodaGenji Kurisu

Abstract

Dynein motors are biologically important bio-nanomachines, and many atomic resolution structures of cytoplasmic dynein components from different organisms have been analyzed by X-ray crystallography, cryo-EM, and NMR spectroscopy. This review provides a historical perspective of structural studies of cytoplasmic and axonemal dynein including accessory proteins. We describe representative structural studies of every component of dynein and summarize them as a structural atlas that classifies the cytoplasmic and axonemal dyneins. Based on our review of all dynein structures in the Protein Data Bank, we raise two important points for understanding the two types of dynein motor and discuss the potential prospects of future structural studies.

References

Jul 30, 1999·Nature Structural Biology·J LiangJ Clardy
Jul 6, 2000·Nature Structural Biology·H WuS M King
Mar 22, 2002·Molecular Biology of the Cell·Paula M GrissomJ Richard McIntosh
Oct 24, 2002·Acta Crystallographica. Section D, Biological Crystallography·Paul D AdamsThomas C Terwilliger
Jan 31, 2003·Proteins·Simon C LovellDavid C Richardson
Mar 1, 2003·Nature·Stan A BurgessKazuhiro Oiwa
Aug 9, 2003·The Journal of Biological Chemistry·Wenning WangMingjie Zhang
Oct 17, 2003·The Biochemical Journal·Catherine L DayMark G Hinds
Feb 10, 2004·Protein Science : a Publication of the Protein Society·Moses MakokhaElisar Barbar
Dec 2, 2004·Acta Crystallographica. Section D, Biological Crystallography·Paul Emsley, Kevin Cowtan
Feb 11, 2005·The Journal of Biological Chemistry·John C WilliamsWayne A Hendrickson
Aug 9, 2005·Journal of Molecular Biology·Udayar IlangovanAndrew P Hinck
Nov 18, 2005·Journal of Molecular Biology·Jikui SongJohn L Markley
Mar 23, 2006·Acta Crystallographica. Section D, Biological Crystallography·Jay Painter, Ethan A Merritt
Sep 15, 2006·Biochemical and Biophysical Research Communications·Jun-Feng LiuDong-Cai Liang
Nov 28, 2006·Molecular and Biochemical Parasitology·Masoud VedadiRaymond Hui
Mar 17, 2007·Annals of the New York Academy of Sciences·Kazuo Inaba
Jun 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·John C WilliamsWayne A Hendrickson
Feb 1, 2008·Biophysical Journal·Kenji Kikushima, Ritsu Kamiya
Jul 25, 2008·The Journal of Biological Chemistry·Christine M LightcapJohn C Williams
Dec 17, 2008·Science·Andrew P CarterI R Gibbons
Feb 10, 2009·Nature Structural & Molecular Biology·Takahide KonKazuo Sutoh
Jul 22, 2009·The Journal of Cell Biology·Ramila S Patel-King, Stephen M King
Sep 18, 2009·The Journal of Biological Chemistry·Justin HallElisar Barbar
Sep 17, 2010·Molecular Biology of the Cell·Panteleimon RompolasStephen M King
Feb 19, 2011·Science·Andrew P CarterRonald D Vale
May 24, 2011·Nature Structural & Molecular Biology·Takahide KonGenji Kurisu
Mar 9, 2012·Nature·Takahide KonGenji Kurisu
Mar 14, 2012·The Journal of Biological Chemistry·Erin M RomesKevin C Slep
Mar 20, 2012·Nature Structural & Molecular Biology·Helgo SchmidtAndrew P Carter
Sep 22, 2012·Science·W B RedwineA E Leschziner
Dec 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Martina TrokterThomas Surrey
Dec 13, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bilal M QureshiNishith Gupta
Mar 14, 2013·The Journal of Biological Chemistry·Pablo GallegoDavid Reverter
Sep 26, 2013·Nature Reviews. Molecular Cell Biology·Anthony J RobertsStan A Burgess
Apr 15, 2014·Nature Cell Biology·Jianfeng LinDaniela Nicastro
Jun 13, 2014·The Journal of Biological Chemistry·Lauren K SlevinKevin C Slep

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Methods Mentioned

BETA
electron microscopy
X-ray
NMR

Software Mentioned

Jpred
Phenix
5NUG
HKL2000
RONN
MolProbity
TLSMD

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