Structural basis and functions of abscisic acid receptors PYLs

Frontiers in Plant Science
Xing L ZhangZhong Z Chen

Abstract

Abscisic acid (ABA) plays a key role in many developmental processes and responses to adaptive stresses in plants. Recently, a new family of nucleocytoplasmic PYR/PYL/RCAR (PYLs) has been identified as bona fide ABA receptors. PYLs together with protein phosphatases type-2C (PP2Cs), Snf1 (Sucrose-non-fermentation 1)-related kinases subfamily 2 (SnRK2s) and downstream substrates constitute the core ABA signaling network. Generally, PP2Cs inactivate SnRK2s kinases by physical interaction and direct dephosphorylation. Upon ABA binding, PYLs change their conformations and then contact and inhibit PP2Cs, thus activating SnRK2s. Here, we reviewed the recent progress in research regarding the structures of the core signaling pathways of ABA, including the (+)-ABA, (-)-ABA and ABA analogs pyrabactin as well as 6AS perception by PYLs, SnRK2s mimicking PYLs in binding PP2Cs. PYLs inhibited PP2Cs in both the presence and absence of ABA and activated SnRK2s. The present review elucidates multiple ABA signal perception and transduction by PYLs, which might shed light on how to design small chemical compounds for improving plant performance in the future.

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Citations

Nov 19, 2015·Frontiers in Plant Science·Belmiro VilelaMarta Riera
Jun 5, 2015·Frontiers in Plant Science·Biswapriya B MisraSixue Chen
Jan 10, 2017·Plant Signaling & Behavior·Jeanne M Harris, Christine A Ondzighi-Assoume
Jul 15, 2017·ACS Chemical Biology·Josie A SilvaroliMarcin Golczak
Jul 10, 2018·Plant & Cell Physiology·Wim DejongheSean R Cutler
Jul 3, 2020·International Journal of Molecular Sciences·Marta GietlerMałgorzata Nykiel
Apr 4, 2019·Plant Molecular Biology·Seungsu HanSangho Lee
Dec 18, 2020·International Journal of Molecular Sciences·Choonkyun JungJong-Joo Cheong
Mar 23, 2019·Journal of Agricultural and Food Chemistry·Chuan WanZhaohai Qin

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Methods Mentioned

BETA
two-hybrid
gel
X-ray
static light scattering
dissection
transgenic
environmental stress
environmental stresses

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