PMID: 9552391Jan 1, 1996Paper

Structural basis for chemical inhibition of CDK2

Progress in Cell Cycle Research
S H KimW F de Azevedo Júnior

Abstract

The central role of cyclin-dependent kinases (CDKs) in cell cycle regulation makes them a promising target for discovering small inhibitory molecules that can modify the degree of cell proliferation. The three-dimensional structure of CDK2 provides a structural foundation for understanding the mechanisms of activation and inhibition of CDK2 and for the discovery of inhibitors. In this article five structures of human CDK2 are summarised: apoprotein, ATP complex, olomoucine complex, isopentenyladenine complex, and des-chloro-flavopiridol complex.

Citations

Oct 3, 2018·Current Medicinal Chemistry·Md Asaduzzaman Khan, Mousumi Tania
Dec 23, 1999·Medicinal Research Reviews·C García-EcheverríaD B Evans
Aug 5, 2000·The Journal of Biological Chemistry·N G OikonomakosL N Johnson
Dec 2, 2008·Journal of Molecular Modeling·Guy Barros BarcellosWalter Filgueira de Azevedo
May 10, 2020·International Journal of Molecular Sciences·Anna HübbersChristian Liedtke
Sep 19, 2003·Biochemical and Biophysical Research Communications·Walter Filgueira de AzevedoDiógenes Santiago Santos
Jan 7, 2004·Biochemical and Biophysical Research Communications·Fernanda CanduriDiógenes Santiago Santos
Nov 16, 2019·Current Medicinal Chemistry·Gabriela Bitencourt-FerreiraWalter Filgueira de Azevedo

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