Abstract
RcsB is a highly conserved transcription regulator of the Rcs phosphorelay system, a complex two-component signal transduction system (N. Majdalani and S. Gottesman, Annu Rev Microbiol 59:379-405, 2005; A. J. Wolfe, Curr Opin Microbiol 13:204-209, 2010, https://doi.org/10.1016/j.mib.2010.01.002; D. J. Clarke, Future Microbiol 5:1173-1184, 2010, https://doi.org/10.2217/fmb.10.83). RcsB plays an important role in virulence and pathogenicity in human hosts by regulating biofilm formation. RcsB can regulate transcription alone or together with its auxiliary transcription regulators by forming heterodimers. This complexity allows RcsB to regulate transcription of more than 600 bacterial genes in response to different stresses (D. Wang et al., Mol Plant Microbe Interact 25:6-17, 2012, https://doi.org/10.1094/MPMI-08-11-0207). Despite increasing knowledge of RcsB importance, molecular mechanisms that drive the ability of RcsB to control transcription of a large number of genes remain unclear. Here, we present crystal structures of unphosphorylated RcsB in complex with the consensus DNA-binding sequence of 22-mer (DNA22) and 18-mer (DNA18) of the flhDC operon from Escherichia coli determined at 3.15- and 3.37-Å resolution, respectively...Continue Reading
References
Jun 1, 1988·Journal of Bacteriology·J A BrillS Gottesman
Sep 9, 1983·Science·Y TakedaB W Matthews
Aug 27, 1996·Biochemistry·I BaikalovR E Dickerson
Jan 28, 1999·The Journal of Biological Chemistry·M WehlandF Bernhard
Mar 6, 1999·Current Opinion in Microbiology·P N Goudreau, A M Stock
Mar 4, 2000·The Journal of Biological Chemistry·M Wehland, F Bernhard
Jun 28, 2002·Nature·Rong-guang ZhangAndrzej Joachimiak
Sep 28, 2002·Nature Structural Biology·Ann E MarisRichard E Dickerson
Nov 2, 2002·Molecular Microbiology·Nadim MajdalaniSusan Gottesman
May 13, 2003·The Journal of Biological Chemistry·Primoz PristovsekFrank Bernhard
Jul 17, 2003·Molecular Microbiology·Anne Francez-CharlotKaymeuang Cam
Jun 17, 2006·Molecular Microbiology·Christine E FredericksAlan J Wolfe
Apr 1, 2008·Microbiology·Stewart J HinchliffeBrendan W Wren
Jan 7, 2009·Journal of Bacteriology·Javier F Mariscotti, Francisco García-del Portillo
Mar 2, 2010·Nucleic Acids Research·Marie-Pierre Castanié-CornetClaude Gutierrez
May 12, 2010·Nucleic Acids Research·Liisa Holm, Päivi Rosenström
Jan 11, 2011·PloS One·Sandy ThaoJorge C Escalante-Semerena
May 15, 2012·Journal of Bacteriology·Cristina LatasaIñigo Lasa
May 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Paul G LeonardAnn M Stock
Jul 16, 2013·Journal of Bacteriology·Linda I HuAlan J Wolfe
Dec 18, 2013·Nucleic Acids Research·Silja Lucia SalscheiderKarin Schnetz
Feb 15, 2014·Nature Communications·Anoop NarayananDinesh A Yernool
Dec 20, 2014·Cell·Seung-Hyun ChoJean-François Collet
Aug 8, 2015·Acta Crystallographica. Section F, Structural Biology Communications·Akihiro DoiHiroshi Sugimoto
Dec 5, 2015·The Journal of Biological Chemistry·Derk PannenKarin Schnetz
Apr 16, 2016·Scientific Reports·Xiaoyuan HeShuishu Wang
May 21, 2016·Molecular Microbiology·Caroline KühneMarc Erhardt
Oct 25, 2016·Protein Science : a Publication of the Protein Society·Ekaterina V FilippovaWayne F Anderson
Nov 16, 2017·Nature Communications·Smarajit ChakrabortyLinda J Kenney
Citations
Dec 19, 2018·PloS One·Linda I HuAlan J Wolfe
May 19, 2019·Annual Review of Microbiology·Rong GaoAnn M Stock
Jun 5, 2020·Microorganisms·Aurélie FerrandAnne Davin-Regli
Jun 27, 2020·Frontiers in Cellular and Infection Microbiology·Lingyue YuanYingli Li
Dec 9, 2020·Cancers·Verona BuocikovaBozena Smolkova
Feb 28, 2021·Nucleic Acids Research·Juanjo HuesaPatricia Casino
Mar 20, 2021·Scientific Reports·Kamonlapat SupimonPa-Thai Yenchitsomanus
Mar 23, 2021·Critical Reviews in Microbiology·Lucindo Cardoso de PinaL Caetano M Antunes
Mar 24, 2021·Journal of Bacteriology·Nickolas G KesslerSean D Moore
Oct 26, 2021·Journal of Bacteriology·Yuki YamanakaKaneyoshi Yamamoto