Structural basis for the decrease in the outward potassium channel current induced by lanthanum.

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Li Hong WangXiao Hua Huang

Abstract

The current of the outward K+ channel in the cell of horseradish treated with La3+ and the direct interaction between La3+ and the K+ channel protein were investigated using the whole-cell patch-clamp technique, molecular dynamics simulation, and quantum chemistry calculation methods. It was found for the first time that La3+ decreases the current of the K+ channel in the horseradish mesophyll cell. The decrease results from the formation of a coordination bond and hydrogen bond between La3+ and the K+ channel protein in the plasma membrane. The direct interaction destroys the native structure of the K+ channel protein, disturbing the function of the K+ channel protein in the cells. The results can provide the theoretical foundation for understanding the interaction between metal ions (especially high-valence metal ions) and the channel protein in organisms, including animal and plant cells.

References

Jan 1, 1995·Annual Review of Biochemistry·W A Catterall
Mar 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y KovtunJ Sheen
Dec 1, 2001·FEBS Letters·N IvashikinaR Hedrich
Jun 19, 2004·The International Journal of Neuroscience·Waleed B Alshuaib, Mini V Mathew
Nov 18, 2005·Neurochemical Research·Waleed B Alshuaib, Mini V Mathew
Jan 13, 2006·Ecotoxicology and Environmental Safety·Q ZengH Y Chu
Sep 15, 2006·Cancer Detection and Prevention·Antonio FelipeEnric Condom
Sep 4, 2007·Nature Materials·S R FoltynM Maley
Feb 16, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Shaofen GuoXiaohua Huang
Apr 9, 2008·Journal of Environmental Monitoring : JEM·T MorenoW Gibbons
Aug 21, 2008·Chemistry, an Asian Journal·Anna F A Peacock, Peter J Sadler
Sep 20, 2008·Environmental Science & Technology·Teresa MorenoWes Gibbons
Feb 25, 2009·Expert Opinion on Drug Metabolism & Toxicology·Amy Barton PaiCharles R McQuade
Jun 23, 2009·Trends in Plant Science·Ingo Dreyer, Michael R Blatt
Aug 5, 2009·Chemical Reviews·Koen Binnemans
Oct 14, 2009·Biochimie·Lihong WangXiaohua Huang

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Citations

Oct 12, 2012·Biological Trace Element Research·Guangmei YangXiaohua Huang
Dec 3, 2014·Ecotoxicology and Environmental Safety·Qing YangXiaohua Huang
Jan 17, 2015·Journal of Hazardous Materials·Petr BabulaMarián Hlavna
Jul 13, 2016·Biochemistry·Konstantin GavriljukKlaus Gerwert
May 2, 2017·Biochemistry·Marco BiancucciKarla J F Satchell
Dec 29, 2020·Physical Chemistry Chemical Physics : PCCP·María Queralt-MartínAntonio Alcaraz

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