PMID: 9532233Apr 9, 1998Paper

Structural basis for the pathophysiology of lipoprotein(a) in the athero-thrombotic process

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
E Anglés-Cano

Abstract

Lipoprotein Lp(a) is a major and independent genetic risk factor for atherosclerosis and cardiovascular disease. The essential difference between Lp(a) and low density lipoproteins (LDL) is apolipoprotein apo(a), a glycoprotein structurally similar to plasminogen, the precursor of plasmin, the fibrinolytic enzyme. This structural homology endows Lp(a) with the capacity to bind to fibrin and to membrane proteins of endothelial cells and monocytes, and thereby to inhibit plasminogen binding and plasmin generation. The inhibition of plasmin generation and the accumulation of Lp(a) on the surface of fibrin and cell membranes favor fibrin and cholesterol deposition at sites of vascular injury. Moreover, insufficient activation of TGF-beta due to low plasmin activity may result in migration and proliferation of smooth muscle cells into the vascular intima. These mechanisms may constitute the basis of the athero-thrombogenic mode of action of Lp(a). It is currently accepted that this effect of Lp(a) is linked to its concentration in plasma. An inverse relationship between Lp(a) concentration and apo(a) isoform size, which is under genetic control, has been documented. Recently, it has been shown that inhibition of plasminogen binding ...Continue Reading

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Citations

Jul 18, 2006·Atherosclerosis·Ana Paula Carlos CândidoGeorge Luiz Lins Machado-Coelho
Aug 25, 2000·Journal of Vascular Surgery·J E FortunatoA M Scanu
Jan 18, 2006·Cadernos de saúde pública·Roberto Briceño-León
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Feb 9, 2016·Indian Journal of Clinical Biochemistry : IJCB·Anjali Manocha, L M Srivastava

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