PMID: 7034770Nov 1, 1981Paper

Structural basis of contraction in vitreal fibrous membranes

The British Journal of Ophthalmology
I Grierson, A H Rahi

Abstract

A combined ultrastructural and immunofluorescent study was conducted on experimentally induced fibrous membranes in the vitreous of adult rabbits. Autochthonous tissue cultured fibroblasts were injected into the mid-vitreous of one eye of each of 25 rabbits. The animals were monitored routinely with an ophthalmoscope and slit-lamp and were killed at various time periods between 5 minutes and 6 months. Appropriate tissue was taken for light microscopy, transmission electron microscopy, scanning electron microscopy, and indirect immunofluorescence. With this model we were able to show that the contractile elements in fibrous membranes are probably modified fibroblasts called myofibroblasts which are most abundant 3 to 6 weeks after injection. This is the time when retinal detachment usually occurs. It is our impression that, as traction membranes develop, there is not so much an increase in the contractile elements of the constituent cells as a rearrangement of the existing cytoplasmic microfilaments into compact highly organised bundles called stress cables. The behaviour and ultrastructural characteristics of intravitreal fibroblasts compare with the action of fibroblasts in the healing of wounds.

References

Feb 22, 1978·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·J Faulborn, T M Topping
Sep 1, 1978·The British Journal of Ophthalmology·A Rahi, N Ashton
Jan 1, 1979·The British Journal of Ophthalmology·I Grierson, A H Rahi
Sep 1, 1979·The Journal of Pathology·J V Forrester, I Grierson
Sep 1, 1977·Surgery, Gynecology & Obstetrics·R RudolphM Woodward
May 26, 1976·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·P Algvere, E Kock
Jul 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·E Lazarides
Nov 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·B J HirschelG Majno
Apr 1, 1972·The Journal of Experimental Medicine·G GabbianiG Majno
Jan 1, 1972·Zeitschrift für Zellforschung und mikroskopische Anatomie·F H GüldnerD G Keyserlingk
Feb 4, 1972·Nature·N B GilulaA Steinbach
Jan 1, 1974·Human Pathology·G B RyanG Majno
Jan 1, 1974·Cell and Tissue Research·K Gorgas, P Böck
Jun 1, 1972·Archives of Ophthalmology·W H Coles, G M Haik
Feb 1, 1969·Circulation Research·S Bloom, P A Cancilla
Sep 1, 1969·The Journal of Cell Biology·G MajnoM Leventhal
Jan 1, 1980·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·I GriersonR C Howes
Jan 1, 1980·American Journal of Ophthalmology·G SugitaG Fiorentino
Nov 1, 1980·The British Journal of Ophthalmology·S R WinthropS J Ryan

❮ Previous
Next ❯

Citations

Feb 1, 1988·Cell and Tissue Research·A C EdmanJ M Squire
Jan 1, 1985·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C A HitchinsP S Hiscott
May 22, 2013·The Journal of Physiological Sciences : JPS·Daisuke MiyashiroTakenori Yamada
Apr 16, 1996·Biophysical Chemistry·G H Pollack
Jan 1, 1989·Meat Science·E O'NeillP A Morrissey
Sep 25, 2002·Journal of Molecular Biology·Carlo KnuppJohn M Squire
Feb 5, 1999·Progress in Retinal and Eye Research·P HiscottI Grierson
Jan 1, 1994·Eye·P K Leaver
Feb 1, 1988·The British Journal of Ophthalmology·D Y JiangD McLeod
Apr 25, 2000·Biochemical and Biophysical Research Communications·R Jarosch
Jan 1, 1986·Connective Tissue Research·C A HitchinsA H Rahi
Sep 24, 2005·International Journal of Clinical Practice·E TsanouN J Agnantis
Oct 29, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Salil S GadkariSucheta Kulkarni
Nov 23, 2017·Vestnik oftalmologii·I P Khoroshilova-MaslovaA V Vasiliev
Apr 1, 1992·Circulation·R H CharneyC Eng
Jun 26, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kevin K Parker, Donald E Ingber

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.