Structural basis of DNA lesion recognition for eukaryotic transcription-coupled nucleotide excision repair

DNA Repair
Wei WangDong Wang

Abstract

Eukaryotic transcription-coupled nucleotide excision repair (TC-NER) is a pathway that removes DNA lesions capable of blocking RNA polymerase II (Pol II) transcription from the template strand. This process is initiated by lesion-arrested Pol II and the recruitment of Cockayne Syndrome B protein (CSB). In this review, we will focus on the lesion recognition steps of eukaryotic TC-NER and summarize the recent research progress toward understanding the structural basis of Pol II-mediated lesion recognition and Pol II-CSB interactions. We will discuss the roles of CSB in both TC-NER initiation and transcription elongation. Finally, we propose an updated model of tripartite lesion recognition and verification for TC-NER in which CSB ensures Pol II-mediated recognition of DNA lesions for TC-NER.

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Citations

Mar 29, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Zivkos ApostolouGeorge A Garinis
Jun 22, 2019·Nucleic Acids Research·Nataliya KitseraAndriy Khobta
Aug 24, 2019·Nature Structural & Molecular Biology·Ronald C Conaway, Joan W Conaway
Sep 29, 2019·Nature Reviews. Molecular Cell Biology·Hannes LansJurgen A Marteijn
Apr 3, 2020·International Journal of Molecular Sciences·Lucia Borszéková PulzováMiroslav Chovanec
Sep 17, 2020·International Journal of Molecular Sciences·Philippe Johann To Berens, Jean Molinier
May 27, 2020·Genetics and Molecular Biology·Alexandre Teixeira VessoniCamila Carrião Machado Garcia
Apr 29, 2019·Methods : a Companion to Methods in Enzymology·Guowu LinGuillermo Calero
Nov 25, 2020·Seminars in Cell & Developmental Biology·Gustavo Satoru KajitaniCarlos Frederico Martins Menck
Jan 14, 2022·Proceedings of the National Academy of Sciences of the United States of America·Juntaek OhDong Wang

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