PMID: 7522675Jun 1, 1994Paper

Structural basis of ion channel permeation and selectivity

Current Opinion in Neurobiology
W A SatherR W Tsien

Abstract

There has been rapid progress in understanding the structural basis of ion selectivity and permeation in both ligand- and voltage-gated channels. Recognition of similarities in overall architecture within a channel class has led to an increasing focus on the specific molecular determinants that endow a channel with its own distinctive character. It has been possible in some cases to identify individual amino acids essential for ion selectivity.

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