Structural basis of receptor recognition by SARS-CoV-2.

Jian ShangFang Li


A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) recently emerged and is rapidly spreading in humans, causing COVID-191,2. A key to tackling this pandemic is to understand the receptor recognition mechanism of the virus, which regulates its infectivity, pathogenesis and host range. SARS-CoV-2 and SARS-CoV recognize the same receptor-angiotensin-converting enzyme 2 (ACE2)-in humans3,4. Here we determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 (engineered to facilitate crystallization) in complex with ACE2. In comparison with the SARS-CoV RBD, an ACE2-binding ridge in SARS-CoV-2 RBD has a more compact conformation; moreover, several residue changes in the SARS-CoV-2 RBD stabilize two virus-binding hotspots at the RBD-ACE2 interface. These structural features of SARS-CoV-2 RBD increase its ACE2-binding affinity. Additionally, we show that RaTG13, a bat coronavirus that is closely related to SARS-CoV-2, also uses human ACE2 as its receptor. The differences among SARS-CoV-2, SARS-CoV and RaTG13 in ACE2 recognition shed light on the potential animal-to-human transmission of SARS-CoV-2. This study provides guidance for intervention strategies that tar...Continue Reading

Associated Clinical Trials


Jun 24, 1992·Journal of Immunological Methods·A J Pesce, J G Michael
Apr 16, 2003·The New England Journal of Medicine·Nelson LeeJoseph J Y Sung
Apr 25, 2003·Lancet·J S M PeirisUNKNOWN SARS study group
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jianhua SuiWayne A Marasco
Dec 2, 2004·Acta Crystallographica. Section D, Biological Crystallography·Paul Emsley, Kevin Cowtan
Mar 26, 2005·The EMBO Journal·Wenhui LiMichael Farzan
Feb 10, 2009·Nature Reviews. Microbiology·Lanying DuShibo Jiang
May 12, 2009·Nature Reviews. Microbiology·Stanley Perlman, Jason Netland
Apr 5, 2011·Acta Crystallographica. Section D, Biological Crystallography·Martyn D WinnKeith S Wilson
Feb 1, 2012·The Journal of Biological Chemistry·Kailang WuFang Li
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yang YangFang Li
Sep 1, 2016·Annual Review of Virology·Fang Li
Jan 1, 1997·Methods in Enzymology·Zbyszek Otwinowski, Wladek Minor
Dec 13, 2016·Expert Opinion on Therapeutic Targets·Lanying DuShibo Jiang
Sep 13, 2018·Scientific Reports·Svetlana PylaevaDaniel Sebastiani
Dec 12, 2018·Nature Reviews. Microbiology·Jie CuiZheng-Li Shi
Oct 8, 2019·Acta Crystallographica. Section D, Structural Biology·Dorothee LiebschnerPaul D Adams
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Mar 11, 2020·Cell·Alexandra C WallsDavid Veesler
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Datasets Mentioned


Methods Mentioned

surface plasmon resonance
gel filtration
immunoprecipitation assay

Software Mentioned

LigPlot +
Biacore Evaluation

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