Structural basis of Staphylococcus epidermidis biofilm formation: mechanisms and molecular interactions

Frontiers in Cellular and Infection Microbiology
Henning BüttnerHolger Rohde

Abstract

Staphylococcus epidermidis is a usually harmless commensal bacterium highly abundant on the human skin. Under defined predisposing conditions, most importantly implantation of a medical device, S. epidermidis, however, can switch from a colonizing to an invasive life style. The emergence of S. epidermidis as an opportunistic pathogen is closely linked to the biofilm forming capability of the species. During the past decades, tremendous advance regarding our understanding of molecular mechanisms contributing to surface colonization has been made, and detailed information is available for several factors active during the primary attachment, accumulative or dispersal phase of biofilm formation. A picture evolved in which distinct factors, though appearing to be redundantly organized, take over specific and exclusive functions during biofilm development. In this review, these mechanisms are described in molecular detail, with a highlight on recent insights into multi-functional S. epidermidis cell surface proteins contributing to surface adherence and intercellular adhesion. The integration of distinct biofilm-promoting factors into regulatory networks is summarized, with an emphasis on mechanism that could allow S. epidermidis to...Continue Reading

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Citations

Nov 2, 2016·Jundishapur Journal of Microbiology·Shahin Najar PeerayehMehrdad Behmanesh
Mar 17, 2016·Journal of Microbiological Methods·Sebastian Schlafer, Rikke L Meyer
Apr 24, 2015·Frontiers in Cellular and Infection Microbiology·Pietro Speziale, Joan A Geoghegan
Jun 12, 2016·Journal of Applied Microbiology·A PiecuchK A Wilk
Feb 28, 2018·Journal of Bacteriology·Julie LiaoPaula I Watnick
Nov 16, 2019·Microorganisms·Aurore VermassenSabine Leroy
Dec 1, 2019·Current Microbiology·Antônio Wilton Cavalcante FernandesMateus Matiuzzi da Costa
Dec 11, 2019·Antimicrobial Agents and Chemotherapy·Jacqueline C Y LaiCarina Mallard
Aug 7, 2017·Journal of Biomedical Materials Research. Part a·Annika JuhlinMargarita Trobos
Jan 23, 2018·Frontiers in Microbiology·Xiuqin QiFangyou Yu
Oct 24, 2019·Molecular Biology Reports·Silvestre Ortega-PeñaJuan C Cancino-Diaz
Jul 19, 2018·Deutsches Ärzteblatt International·Michael DöringGerhard Hindricks
Apr 4, 2021·International Journal of Environmental Research and Public Health·Artur NiedzielskiTomasz Stankiewicz
Jun 8, 2021·Frontiers in Microbiology·Radha P SomarathneNicholas C Fitzkee
Apr 20, 2018·ACS Applied Materials & Interfaces·Anusha AdityaMunia Ganguli
Apr 1, 2020·ACS Omega·Danica J WalshPhilip S Stewart

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Methods Mentioned

BETA
NMR
phage display
confocal microscopy
X-ray

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