PMID: 9647416Jul 1, 1998Paper

Structural, biochemical and functional effects of distending pressure in the human saphenous vein: implications for bypass grafting

Coronary Artery Disease
A H ChesterM H Yacoub

Abstract

Distension of the saphenous vein before and after coronary artery bypass grafting results in damage to mechanisms that regulate vascular tone. We have investigated the relationship between the magnitude of distending pressure and the degree of structural, biochemical and functional damage to the vessel wall. Vessel segments that had been distended to either 100 or 300 mmHg were set up in isolated organ baths and the function of the smooth muscle and endothelial cells examined. All segments examined were then fixed for assessment of structural damage by scanning electron microscopy and for immunocytochemical localisation of endothelial nitric oxide synthase. Segments of saphenous vein distended to 100 mmHg retained their responsiveness to KCl (90 mmol/l) and phenylephrine (10(-6) mol/l), but those pressurised to 300 mmHg had significantly reduced responses to both agents. There was also a significant reduction in response to the endothelium-dependent dilators, acetylcholine (10(-10)-10(-6) mol/l) and bradykinin (10(-10)-10(-6) mol/l) in those segments distended to 300 mmHg. Quantitative studies of structural endothelial damage showed a significant loss of endothelium at 300 mmHg distension pressure. Remaining endothelial cells r...Continue Reading

Citations

Jan 17, 2004·The Annals of Thoracic Surgery·Elena B OkonCornelis van Breemen
Mar 16, 2012·Cardiology in Review·Kimberly DaoGeorge Hines
Jan 12, 2010·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Fernanda ViaroPaulo Roberto Barbosa Evora
Dec 10, 2017·Journal of Biomechanical Engineering·Keith J GoochBenjamin W Scandling
Nov 13, 2019·Journal of Cardiovascular Translational Research·Chao YuanGuo-Wei He

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