Structural, biological and pharmaceutical importance of antibiotic agent chloramphenicol

Heliyon
A SathyaS Ramalingam

Abstract

The vibrational, magnetic resonance and electronic spectral techniques are used to evaluate structural activity associated physico-chemical properties. The biological affinity and drug importance was validated by calculating biological parameters using HyperChem. Mulliken charge assignment for restoring chemical potential for generating drug potential in the molecular site was mapped and analyzed. The vibrational spectral pattern was estimated by identifying active and inactive bands and hindrance of vibrational activity of Acetamide group was monitored and thereby drug malfunction was tested. The chemical reaction pathway around the core carbons of chain and ring was keenly noted and the cause of chemical potential for the inducement of drug mechanism was reported. The stimulation of chemical mechanism for antibiotic activity was addressed by suitable evidence and further improvement for enhancing activity was made. The electronic HOMO and LUMO interaction over different molecular entities are discussed to expose accompany of drug mechanical transitions. The CT complex was recognized to be C=N and C=C bonds and operating drug mechanism was monitored. The unwanted drug property induced by perplexes of charge depletion on α-hydr...Continue Reading

References

Apr 1, 1999·Human & Experimental Toxicology·D E Holt, R Bajoria
Nov 25, 2003·Inorganic Chemistry·Fabienne Bessac, Gernot Frenking
Jun 14, 2005·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·V KrishnakumarT Chithambarathanu
Aug 15, 2006·Inorganic Chemistry·Fabienne Bessac, Gernot Frenking
Apr 28, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jianzhong ShenShuangyang Ding
Oct 28, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Pengjie LuoJianzhong Shen
Oct 30, 2009·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·C S Hiremath, Tom Sundius
May 13, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·D MahadevanS Ramalingam
Nov 11, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·R John Xavier, E Gobinath
Mar 9, 2019·Physical Chemistry Chemical Physics : PCCP·Timothy D ScarboroughCornelis J G J Uiterwaal

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Citations

Aug 28, 2021·International Journal of Environmental Research and Public Health·Yanyan WangKuncai Chen

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Methods Mentioned

BETA
NMR

Software Mentioned

GAUSSIAN
HyperChem
Osiris
MLP
CPK

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