Structural biology data archiving - where we are and what lies ahead

FEBS Letters
Gerard J KleywegtArdan Patwardhan

Abstract

For almost 50 years, structural biology has endeavoured to conserve and share its experimental data and their interpretations (usually, atomistic models) through global public archives such as the Protein Data Bank, Electron Microscopy Data Bank and Biological Magnetic Resonance Data Bank (BMRB). These archives are treasure troves of freely accessible data that document our quest for molecular or atomic understanding of biological function and processes in health and disease. They have prepared the field to tackle new archiving challenges as more and more (combinations of) techniques are being utilized to elucidate structure at ever increasing length scales. Furthermore, the field has made substantial efforts to develop validation methods that help users to assess the reliability of structures and to identify the most appropriate data for their needs. In this Review, we present an overview of public data archives in structural biology and discuss the importance of validation for users and producers of structural data. Finally, we sketch our efforts to integrate structural data with bioimaging data and with other sources of biological data. This will make relevant structural information available and more easily discoverable for...Continue Reading

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Citations

Jun 26, 2018·FEBS Letters·Wilhelm Just
Sep 4, 2019·International Reviews of Immunology·Armina Alagheband BahramiMojgan Bandehpour
Nov 11, 2018·The Biochemical Journal·Marcelo Lattarulo CamposOctávio Luiz Franco
Jun 14, 2019·Frontiers in Behavioral Neuroscience·Richard E Brown

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Datasets Mentioned

BETA
EMPIAR

Methods Mentioned

BETA
nuclear
scanning electron microscopy
nuclear magnetic resonance
NMR
X‐ray
in
such
light microscopy

Software Mentioned

EM
wwPDB
CSD
FunPDBe
EMDataBank
COD
EMDB
cryo
SASBDB
OneDep

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