Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies

Molecular Immunology
Tamir DingjanPaul A Ramsland

Abstract

Monoclonal antibodies represent the most successful class of biopharmaceuticals for the treatment of cancer. Mechanisms of action of therapeutic antibodies are very diverse and reflect their ability to engage in antibody-dependent effector mechanisms, internalize to deliver cytotoxic payloads, and display direct effects on cells by lysis or by modulating the biological pathways of their target antigens. Importantly, one of the universal changes in cancer is glycosylation and carbohydrate-binding antibodies can be produced to selectively recognize tumor cells over normal tissues. A promising group of cell surface antibody targets consists of carbohydrates presented as glycolipids or glycoproteins. In this review, we outline the basic principles of antibody-based targeting of carbohydrate antigens in cancer. We also present a detailed structural view of antibody recognition and the conformational properties of a series of related tissue-blood group (Lewis) carbohydrates that are being pursued as potential targets of cancer immunotherapy.

References

Sep 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P L Devine, I F McKenzie
May 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Singhal, S Hakomori
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L H PaiI Pastan
Feb 1, 1995·Protein Engineering·A C WallaceJ M Thornton
Jun 1, 1995·Nature Structural Biology·P D JeffreyS Sheriff
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·K KitamuraL J Old
Oct 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G SchlimokG Riethmüller
Jun 1, 1997·Journal of Structural Biology·S L PichlaR M Burnett
Oct 23, 1997·International Journal of Cancer. Journal International Du Cancer·S ZhangP O Livingston
Dec 11, 1999·Nucleic Acids Research·H M BermanP E Bourne
Aug 19, 2000·Cancer Chemotherapy and Pharmacology·N HanaiK Shitara
Nov 25, 2003·The Journal of Biological Chemistry·Ute KrengelErnesto Moreno
Jun 15, 2004·Nature Structural & Molecular Biology·Yuan GuoKurt Drickamer
Jun 30, 2004·Journal of Molecular Biology·Paul A RamslandAndrew M Scott
Jul 10, 2004·Structure·Anne-Marie M van RoonJan Pieter Abrahams
May 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Robert BrodzikHilary Koprowski
Aug 29, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Helen J RossCharles M Rudin
Sep 12, 2006·The Journal of Pharmacology and Experimental Therapeutics·Hesso FarhanRalf Kircheis
Mar 17, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Amir H Iranpour FeridaniBo Baldetorp
Jun 5, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew M ScottLloyd J Old
Jul 23, 2008·Molecular Cancer Therapeutics·Lourdes Roque-NavarroRolando Pérez
Aug 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Cheng-Chi WangChi-Huey Wong
Sep 3, 2009·Chemical Communications : Chem Comm·Therese BuskasGeert-Jan Boons
Oct 15, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rebecca A HerbertsonAndrew M Scott
Dec 17, 2009·Journal of Experimental & Clinical Cancer Research : CR·Juanjuan LiuMasao Iwamori
Mar 17, 2010·Carbohydrate Research·Aurélie CazetPhilippe Delannoy
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cory L BrooksStephen V Evans
Jun 17, 2010·Breast Cancer Research : BCR·Aurélie CazetPhilippe Delannoy
Jan 25, 2011·Angewandte Chemie·Tongzhong JuRichard D Cummings
Jul 20, 2011·ACS Chemical Biology·Yuelong MaAndrew M Scott
Sep 17, 2011·Journal of Chemical Information and Modeling·Roman A Laskowski, Mark B Swindells
Oct 4, 2011·Vaccine·Jamie Heimburg-MolinaroKate Rittenhouse-Olson

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Citations

May 21, 2015·Molecular Immunology·Paul A RamslandPaul J Carter
Jun 27, 2015·Frontiers in Immunology·Elizabeth Yuriev, Paul A Ramsland
Nov 9, 2016·Current Opinion in Structural Biology·Caroline SolimanPaul A Ramsland
Feb 18, 2017·British Journal of Haematology·Slavica VuckovicAndrew T Hutchinson
Oct 1, 2015·Chemical Communications : Chem Comm·Sheng-Kai Wang, Chao-Min Cheng
Dec 3, 2016·Biochemistry. Biokhimii︠a︡·E V SheshukovaY L Dorokhov
Aug 14, 2020·The Biochemical Journal·Caroline SolimanPaul A Ramsland
Jun 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dapeng ZhouTorsten Tonn
Apr 22, 2021·The Biochemical Journal·J Sebastian TemmeJeffrey C Gildersleeve
May 16, 2021·Protein Engineering, Design & Selection : PEDS·Kasandra Bélanger, Jamshid Tanha
May 29, 2021·Acta Biomaterialia·Hanmei LiQiang Peng
Jun 24, 2021·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Magdalena Thurin

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