Structural Bone Deficits in HIV/HCV-Coinfected, HCV-Monoinfected, and HIV-Monoinfected Women

The Journal of Infectious Diseases
Vincent Lo ReMary B Leonard

Abstract

Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is associated with reduced bone mineral density (BMD) and increased fracture rates, particularly in women. The structural underpinnings for skeletal fragility in coinfected women have not been characterized. We used tibial peripheral quantitative computed tomography to evaluate skeletal parameters in women, by HIV/HCV status. We conducted a cross-sectional study among 50 HIV/HCV-coinfected, 51 HCV-monoinfected, and 50 HIV-monoinfected women. Tibial volumetric BMD and cortical dimensions were determined with peripheral quantitative computed tomography. Race-specific z scores for age were generated using 263 female reference participants without HIV infection or liver disease. Coinfected participants had lower mean z scores for trabecular volumetric BMD (-0.85), cortical volumetric BMD (-0.67), cortical area (-0.61), and cortical thickness (-0.77) than reference participants (all P < .001). The smaller cortical dimensions were due to greater mean z scores for endosteal circumference (+0.67; P < .001) and comparable z scores for periosteal circumference (+0.04; P = .87). Trabecular volumetric BMD was lower in coinfected than in HCV- or HIV-monoinfected...Continue Reading

References

Oct 1, 1994·Journal of General Internal Medicine·J H IsaacsonA Tzelepis
Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
Aug 19, 1999·The New England Journal of Medicine·M J AlterH S Margolis
Sep 19, 2000·Medicine and Science in Sports and Exercise·B E AinsworthA S Leon
Dec 22, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Rouillard, N E Lane
Feb 8, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kenneth E ShermanNatasa Rajicic
Oct 25, 2002·American Journal of Epidemiology·Diane E BildRussell P Tracy
Sep 2, 2003·Gastroenterology·William D LeslieUNKNOWN American Gastroenterological Association Clinical Practice Commitee
Oct 16, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C M ShikumaUNKNOWN AIDS Clinical Trial Group 892 Team
Dec 24, 2004·Journal of Bone and Mineral Metabolism·Leonard Rosenthall, Julian Falutz
Dec 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Valerianna Amorosa, Pablo Tebas
Feb 3, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D LiuH A McKay
Feb 15, 2007·The Journal of Clinical Endocrinology and Metabolism·Lan-Juan ZhaoHong-Wen Deng
Jun 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael P DubéSteven K Grinspoon
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Apr 30, 2008·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Sanford BaimFrank Rauch
Sep 16, 2009·PloS One·Thomas L KellySteven B Heymsfield
Dec 8, 2009·The Journal of Clinical Endocrinology and Metabolism·Michael T YinElizabeth Shane
May 7, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Andrew N HoofnagleThomas F Donaldson
Sep 11, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hans-Jürgen StellbrinkUNKNOWN ASSERT Study Group
Sep 16, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Grace A McComseyTodd T Brown
Mar 2, 2011·PloS One·Julie A WomackUNKNOWN Veterans Aging Cohort Study Project Team
Mar 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin YoungUNKNOWN HIV Outpatient Study (HOPS) Investigators
Sep 9, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V Walker HarrisT T Brown
May 24, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vincent Lo ReA Russell Localio
Oct 4, 2012·Kidney International·Anne TsampalierosMary B Leonard
Nov 10, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A CalmyR Rizzoli
Jan 9, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sylvie Lawson-AyayiUNKNOWN Groupe Epidémiologie Clinique du SIDA en Aquitaine (GECSA)
Apr 18, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Todd T BrownGrace A McComsey
May 22, 2013·The Journal of Clinical Endocrinology and Metabolism·Anne TsampalierosMary B Leonard

❮ Previous
Next ❯

Citations

Apr 12, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Vincent Lo ReJay R Kostman
Jun 9, 2016·Journal of Internal Medicine·J Compston
Feb 2, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M T YinE Shane
Feb 19, 2016·Current Opinion in HIV and AIDS·Roger BedimoVincent Lo Re
Oct 13, 2016·Current HIV/AIDS Reports·Michael T Yin, Todd T Brown
Jun 26, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Anjali SharmaMichael T Yin
May 30, 2019·AIDS Care·Lalita WattanachanyaUNKNOWN TNT 003 study team
Sep 16, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ana CarreroUNKNOWN Grupo de Estudio del Sida (GESIDA) 3603B Study Group
Aug 6, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Thomas DienemannMary B Leonard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.