Structural brain abnormalities in adolescents and young adults with congenital heart defect: a systematic review

Developmental Medicine and Child Neurology
Marie-Eve BolducMarie Brossard-Racine

Abstract

The primary objective of this systematic review is to define and quantify brain structural abnormalities present in adolescents and young adults with complex congenital heart defect (CHD). We also aim to evaluate the extent to which these structural abnormalities are associated with functional outcomes. A search of studies examining brain structure by magnetic resonance imaging in adolescents and young adults with complex CHD was performed in Embase, MEDLINE, and Web of Science. A meta-analysis was conducted to determine the odds of brain abnormalities in young people with CHD. Results not included in the meta-analysis were collated using descriptive statistics. Two hundred and fifty-four studies were identified through the literature search. Among these, 14 original studies were included in the review. The odds of brain abnormalities in young people with CHD were 7.9 times higher (p<0.001) than in typically developing comparison individuals. Focal and multifocal lesions were the most common types of abnormality (odds ratio 22.5 [p<0.001]). Preliminary evidence from volumetric, cortical, and microstructural integrity measurements suggests that brain abnormalities are associated with poorer neurocognitive outcomes. This review p...Continue Reading

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Citations

Apr 6, 2019·Developmental Medicine and Child Neurology
Oct 30, 2019·World Journal for Pediatric & Congenital Heart Surgery·Kathleen R RyanAmy Jo Lisanti
Jul 24, 2020·Cardiology in the Young·Adam R Cassidy
Jul 29, 2020·AJNR. American Journal of Neuroradiology·K FontesM Brossard-Racine
Jan 31, 2021·Brain Imaging and Behavior·Nadja NaefRuth Tuura O'Gorman

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