Structural Brain Changes in Blepharospasm: A Cortical Thickness and Diffusion Tensor Imaging Study

Frontiers in Neuroscience
Yaomin GuoGang Liu

Abstract

White matter abnormalities in blepharospasm (BSP) have been evaluated using conventional intra-voxel metrics, and changes in patterns of cortical thickness in BSP remain controversial. We aimed to determine whether local diffusion homogeneity, an inter-voxel diffusivity metric, could be valuable in detecting white matter abnormalities for BSP; whether these changes are related to disease features; and whether cortical thickness changes occur in BSP patients. Diffusion tensor and structural magnetic resonance imaging were collected for 29 patients with BSP and 30 healthy controls. Intergroup diffusion differences were compared using tract-based spatial statistics analysis and measures of cortical thickness were obtained. The relationship among cortical thickness, diffusion metric in significantly different regions, and behavioral measures were further assessed. There were no significant differences in cortical thickness and fractional anisotropy between the groups. Local diffusion homogeneity was higher in BSP patients than controls, primarily in the left superior longitudinal fasciculus, corpus callosum, left posterior corona radiata, and left posterior thalamic radiata (P < 0.05, family-wise error corrected). The local diffusi...Continue Reading

References

Sep 1, 1983·Neurology·J Jankovic, S C Patel
Mar 5, 2003·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Robert S BakerCharles D Smith
Jun 11, 2003·Neurology·Kerstin E SchmidtAlina A Zubcov
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON
May 13, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·T EtgenD Sander
Feb 28, 2007·Journal of Neurology·Yukihisa SuzukiKenji Ishii
Apr 20, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Mark ObermannMatthias Maschke
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew L AlexanderAaron S Field
Nov 30, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Paulo BugalhoMiguel Xavier
Jan 26, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G FabbriniA Berardelli
Dec 5, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Joseph JankovicGeorge Comes
Aug 26, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Gabriela Gonzalez AlemánFederico Micheli
Jul 1, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Davide MartinoGiovanni Defazio
Jan 11, 2012·Journal of Neural Transmission·Bettina Wabbels, Peter Roggenkämper
Jan 18, 2012·NeuroImage·Bruce Fischl
Dec 6, 2012·Translational Neurodegeneration·Silvina G HorovitzMark Hallett
Feb 27, 2013·Frontiers in Human Neuroscience·Zaixu CuiGaolang Gong
May 8, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Alberto AlbaneseJan K Teller
Jun 12, 2013·Journal of the Neurological Sciences·M A KhooshnoodiH A Jinnah
Mar 22, 2014·NeuroImage·Christopher G SchwarzUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 6, 2014·Journal of Neurology·Jing YangHui-Fang Shang
Feb 12, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Giovanni DefazioAlfredo Berardelli
Jun 21, 2017·Stroke; a Journal of Cerebral Circulation·Gang LiuJinsheng Zeng

❮ Previous
Next ❯

Citations

Jul 29, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Yaomin GuoGang Liu
Aug 20, 2021·Brain Imaging and Behavior·Yichen ZhangRuiwang Huang

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Software Mentioned

SPSS
FreeSurfer
PANDA Pipeline for Analyzing Brain Diffusion Images
TBSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon Ika Daigaku zasshi
T Takazawa
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
R SuwanikP Saguansri
© 2021 Meta ULC. All rights reserved