Structural brain changes in perinatally HIV-infected young adolescents in South Africa

AIDS
Jacqueline HoareDan J Stein

Abstract

To describe the structural brain changes, neurocognitive and mental health associations in adolescents perinatally infected with HIV-1 infection. Cross-sectional. Two hundred and four adolescents with perinatally acquired HIV and 44 uninfected frequency-matched controls aged 9-11 years were enrolled within the Cape Town Adolescent Antiretroviral Cohort. Diffusion tensor imaging and structural brain MRI was done to determine fractional anisotropy, mean diffusivity, grey and white matter volumes, cortical thickness and cortical surfractional anisotropy area. Correlation coefficients were calculated between total grey and white matter volume, cortical surface area, cortical thickness, whole brain fractional anisotropy and whole brain mean diffusivity and clinical and laboratory parameters including general intellectual functioning, Becks Youth Inventory, Child Motivation Scale and Child Behaviour Checklist. HIV-infected adolescents performed worse than controls on the Wechsler Abbreviated Scale of Intelligence (WASI; P < 0.01). HIV-infected adolescents had significant fractional anisotropy decreases, mean diffusivity increases and decreases in cerebral grey matter volumes, cortical surface area and decreased gyrification. Whole-br...Continue Reading

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Citations

Feb 8, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jacqueline HoareDan J Stein
Feb 8, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jennifer JaoUNKNOWN Pediatric HIV/AIDS Cohort Study
Sep 17, 2020·Paediatric Drugs·Adam W BartlettStephen J Kerr
Mar 28, 2020·International Journal of Behavioral Medicine·Derrick SsewanyanaAmina Abubakar
Jun 6, 2019·Journal of Neurovirology·Stéfan Du PlessisJacqueline Hoare
Jan 13, 2021·AIDS Research and Human Retroviruses·Jielan LiZhaoxiang Ye
Apr 28, 2019·NeuroImage. Clinical·Benjamin S C WadeUNKNOWN PREDICT and Resilience Study Groups

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