Structural brain correlates of fatigue in older adults with and without Parkinson's disease

NeuroImage. Clinical
Benzi M KlugerCatherine Price

Abstract

Fatigue is one of the most common and disabling nonmotor symptoms seen in Parkinson's disease (PD) and is also commonly seen in healthy older adults. Our understanding of the etiology of fatigue in older adults with or without PD is limited and it remains unclear whether fatigue in PD is specifically related to PD pathology. The objective of this study was thus to determine whether fatigue in PD was associated with structural changes in gray or white matter and explore whether these changes were similar in older adults without PD. Magnetic resonance imaging (T1 weighted) and diffusion tensor imaging were performed in 60 patients with PD (17 females; age = 67.58 ± 5.51; disease duration = 5.67 ± 5.83 years) and 41 age- and sex- matched healthy controls. FSL image processing was used to measure gray matter volume, fractional anisotropy, and leukoariosis differences. Voxel-based morphometry confirmed gray matter loss across the dorsal striatum and insula in the PD patient cohort. PD patients with fatigue had reduced gray matter volume in dorsal striatum relative to PD patients without fatigue (P < 0.05 False Discovery Rate corrected). No significant fatigue-related structural atrophy was found in controls. There were no areas of s...Continue Reading

Citations

Jul 1, 2020·Journal of Neural Transmission·Mattia SicilianoAlessandro Tessitore
Aug 1, 2020·Aging Clinical and Experimental Research·Davide AngioniPhilipe de Souto Barreto
Jan 3, 2020·Journal of Neural Transmission·Suk Yun KangNa-Young Shin
Jan 16, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Annapoorna Kuppuswamy
Feb 27, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Stacey Li Hi ShingPeter Bede
May 29, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Qu TianCaterina Rosano
Sep 28, 2021·International Journal of Stroke : Official Journal of the International Stroke Society·Georgia CotterNatalia Egorova-Brumley

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