Structural brain imaging in biological psychiatry

British Medical Bulletin
S Lewis

Abstract

The application of X-ray CT and magnetic resonance imaging to the study of brain structure in psychiatry research is reviewed. In schizophrenia, CT showed minor enlargements of fluid spaces; MR has shown volume reductions in medial temporal lobe structures and, most recently, general cortical grey matter. In affective disorders, subcortical white matter lesions seem to characterise particular subgroups. In childhood autism, no clear consensus has emerged despite earlier claims for cerebellar pathology. In dementia, medial temporal changes can be detected reliably in Alzheimer's disease and are of diagnostic and prognostic importance.

Citations

Apr 1, 1997·Current Opinion in Neurobiology·P J Harrison
Oct 20, 2001·Journal of the History of the Neurosciences·J T RichardsonI Robinson
Aug 10, 2000·Journal of Child and Adolescent Psychopharmacology·E H SholevarT L Hardie
Jan 31, 2002·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·J Meinhardt, J Müller
Mar 14, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Timothy P L RobertsSusan E Levy
Sep 1, 1999·Acta Neuropsychiatrica·N Van Eyken, H D'haenen
May 21, 1999·The Australian and New Zealand Journal of Psychiatry·E Gordon

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