Structural Changes Associated with Delayed Dark Adaptation in Age-Related Macular Degeneration

Ophthalmology
Inês LaínsDeeba Husain

Abstract

To examine the relationship between dark adaptation (DA) and optical coherence tomography (OCT)-based macular morphology in age-related macular degeneration (AMD). Prospective, cross-sectional study. Patients with AMD and a comparison group (>50 years) without any vitreoretinal disease. All participants were imaged with spectral-domain OCT and color fundus photographs, and then staged for AMD (Age-related Eye Disease Study system). Both eyes were tested with the AdaptDx (MacuLogix, Middletown, PA) DA extended protocol (20 minutes). A software program was developed to map the DA testing spot (2° circle, 5° superior to the fovea) to the OCT B-scans. Two independent graders evaluated the B-scans within this testing spot, as well as the entire macula, recording the presence of several AMD-associated abnormalities. Multilevel mixed-effects models (accounting for correlated outcomes between 2 eyes) were used for analyses. The primary outcome was rod-intercept time (RIT), defined in minutes, as a continuous variable. For subjects unable to reach RIT within the 20 minutes of testing, the value of 20 was assigned. We included 137 eyes (n = 77 subjects), 72.3% (n = 99 eyes) with AMD and the remainder belonging to the comparison group. Mu...Continue Reading

Citations

Jan 2, 2018·BioResearch Open Access·Walter H MoosKrishna Kodukula
Aug 15, 2018·Investigative Ophthalmology & Visual Science·Rose TanChi D Luu
Mar 19, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Clara RamonJordi Monés
Feb 15, 2020·Investigative Ophthalmology & Visual Science·Miin RohDeeba Husain
Aug 25, 2020·Acta Ophthalmologica·Thomas Richard Johansen ForshawTorben Lykke Sørensen
Aug 15, 2018·Investigative Ophthalmology & Visual Science·Alison M BinnsDavid P Crabb
Apr 20, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Chia-Chieh HsiaoChang-Hao Yang
Feb 5, 2021·The British Journal of Ophthalmology·Karen M WaiJohn B Miller
Apr 17, 2021·Scientific Reports·Bethany E HigginsDavid P Crabb
Apr 24, 2021·The British Journal of Ophthalmology·Shrinivas PundlikDeeba Husain
Aug 16, 2021·The Journal of Biological Chemistry·Dan ZhangIlyas Washington
Aug 31, 2021·Journal of Vitreoretinal Diseases·Merina ThomasJohn B Miller

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