Structural changes in endocrine pancreas of male Wistar rats due to chronic cola drink consumption. Role of PDX-1.

PloS One
Gabriel CaoJosé Milei

Abstract

The objective of this work was to analyze the structural changes of the pancreatic islets in rats, after 6 month consuming regular and light cola for 6 months. Also, we have analyzed the possible role of PDX-1 in that process. Finally, with the available knowledge, we propose a general working hypothesis that explains the succession of phenomena observed. Previously, we reported evidence showing that chronic cola consumption in rats impairs pancreatic metabolism of insulin and glucagon and produces some alterations typically observed in the metabolic syndrome, with an increase in oxidative stress. Of note It is worth mentioning that no apoptosis nor proliferation of islet cells could be demonstrated. In the present study, 36 male Wistar rats were divided into three groups to and given free access to freely drink regular cola (C), light cola (L), or water (W, control). We assessed the impact of the three different beverages in on glucose tolerance, lipid levels, creatinine levels and immunohistochemical changes addressed for the expression of insulin, glucagon, PDX-1 and NGN3 in islet cells, to evaluate the possible participation of PDX-1 in the changes observed in α and β cells after 6 months of treatment. Moreover, we assessed...Continue Reading

References

Jan 1, 1975·Metabolism: Clinical and Experimental·S S AndrewsW G Blackard
Aug 1, 1982·The Journal of Nutrition·R B Kanarek, N Orthen-Gambill
Nov 26, 2002·Behavioural Brain Research·Gaetano Di Chiara
Dec 28, 2002·Diabetes·Alexandra E ButlerPeter C Butler
Aug 26, 2004·JAMA : the Journal of the American Medical Association·Matthias B SchulzeFrank B Hu
Nov 25, 2004·American Journal of Physiology. Endocrinology and Metabolism·Marcela BrissovaAlvin C Powers
Jun 21, 2005·Regulatory Peptides·Andreas LindqvistCharlotte Erlanson-Albertsson
Nov 11, 2005·American Journal of Therapeutics·Hideaki KanetoYoshimitsu Yamasaki
Mar 1, 2007·Diagnostic Pathology·Nhu-An PhamDavid W Hedley
Oct 27, 2007·Journal of Ethnopharmacology·Elena Matteucci, Ottavio Giampietro
Mar 28, 2008·Neuron·Ivan E de AraujoSidney A Simon
Jul 17, 2008·Regulatory Peptides·Andreas LindqvistCharlotte Erlanson-Albertsson
Oct 8, 2009·Diabetes Care·Rebecca J BrownKristina I Rother
Oct 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mira M SachdevaDoris A Stoffers
Feb 9, 2010·Physiology & Behavior·Frank B Hu, Vasanti S Malik
Apr 7, 2010·Nature Reviews. Gastroenterology & Hepatology·Jung Sub LimRobert H Lustig
Jun 25, 2010·Diabetology & Metabolic Syndrome·Jose D BotezelliMaria A Mello
Nov 9, 2010·International Journal of Cardiology·Matilde E Otero-LosadaJosé Milei
Nov 26, 2010·Islets·J Michael Rukstalis, Joel F Habener
Apr 21, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Marta Y Pepino, Christina Bourne
Apr 29, 2011·World Journal of Cardiology·José MileiGiuseppe Ambrosio
Jul 15, 2011·The American Journal of Clinical Nutrition·Jean A WelshMiriam B Vos
Jul 30, 2011·European Journal of Nutrition·Anastasia SheludiakovaRobert A Boakes
Mar 14, 2012·Diabetes Care·Rebecca J BrownKristina I Rother
Nov 21, 2012·Nature Reviews. Endocrinology·Vasanti S MalikFrank B Hu
Apr 4, 2013·Cardiovascular Diabetology·Matilde E Otero-LosadaJosé Milei
Mar 19, 2014·Neurochemical Research·Selina AhmedIain S McGregor
Mar 22, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel C Castro, Kent C Berridge
Sep 27, 2014·Cell Death and Differentiation·G FilomeniF Cecconi
Dec 3, 2014·Physiology & Behavior·Danielle L Colley, Thomas W Castonguay
Mar 21, 2015·International Journal of Molecular Sciences·Hideaki Kaneto, Taka-aki Matsuoka
Jan 1, 2015·Nature Reviews. Disease Primers·Ralph A DeFronzoRam Weiss
Jan 25, 2018·Diabetes, Obesity & Metabolism·Michael A Nauck, Juris J Meier

❮ Previous
Next ❯

Software Mentioned

SPSS
Image
Pro Plus
Adobe Photoshop

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms