PMID: 32145160Jan 1, 2019Paper

Structural changes in myocardium of aged rats on background at stress-induced arterial hypertension

Advances in Gerontology = Uspekhi Gerontologii
L V Babiichuk, V G Babiichuk

Abstract

Here, we assessed the histological changes in myocardial structure in old rats against the background of persistent arterial hypertension. This study was aimed to investigate the structural organization of tissues and vessels of animal myocardium to days 3, 7 and 30 after development of stress-induced arterial hypertension. The experiments were performed in 28-30-month-old white outbred male rats. The pathological state was simulated according to the patented technique under specialized cage conditions with a combined impact of stimuli (light, sound, electricity). Histological and histochemical assessments of the myocardium within these research terms showed the development of destructive and dystrophic disorders in myocardial tissues and vessels, the progression of interstitial and perivascular oedema, the occurrence of diapedetic hemorrhages. Significant differences in morphological structure of the myocardium in hypertensive old rats as compared with the control normotensive animals were established. These findings make it possible to clarify the pathogenesis of the stress-induced arterial hypertension development, which is a key element in designing the current anti-stress and antihypertensive therapy.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.