PMID: 1202014Dec 1, 1975Paper

Structural changes in the membrane of vero cells infected with a paramyxovirus

The Journal of Cell Biology
M Dubois-Dalcq, T S Reese

Abstract

Vero cells productively infected with the Halle strain of measles virus have been studied by means of surface replication, freeze-fracturing, and surface labeling with horseradish peroxidase-measles antibody conjugate in order to examine changes in the structure of the cell membrane during viral maturation. Early in infection, the surfaces of infected cells are embossed by scattered groups of twisted strands, and diffuse patches of label for viral antigens cover regions marked by these strands. At later stages, when numerous nucleocapsids become aligned under the plasmalemmal strands, the strands increase in number and width and become more convoluted. At this stage, label for viral antigens on the surface of the cell membrane is organized into stripes lying on the crests of strands. Finally, regions of the membrane displaying twisted strands protrude to form ridges or bulges, and the freeze-fractured membrane surrounding these protrusions is characterized by an abundance of particles small than those found on the rest of the cell membrane. The fractured membranes of viral buds are continuous sheets of these small particles, and the spacing between both nucleocapsids and stripes of surface antigen in buds is less than in the su...Continue Reading

References

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Citations

Jan 1, 1980·Pharmacology & Therapeutics·L Carrasco, A E Smith
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J B Wade, R A Coleman
Mar 6, 2002·The Journal of Experimental Medicine·Sina BavariM Javad Aman
Oct 12, 2000·Journal of Virology·S VincentS N Manié
Jun 10, 2003·Microbiology and Molecular Biology Reviews : MMBR·Nathalie Chazal, Denis Gerlier
Jan 1, 1978·Journal of Ultrastructure Research·A DemseyC W Stackpole
Oct 15, 1976·Virology·M Dubois-DalcqO Narayan
Oct 15, 1983·Virology·W BohnK Mannweiler
Dec 22, 1999·Virology·S VincentD Gerlier
Nov 1, 1978·Journal of Virology·B RentierM Dubois-Dalcq

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