Structural changes in the somatosensory system correlate with tic severity in Gilles de la Tourette syndrome

Brain : a Journal of Neurology
Götz ThomallaAlexander Münchau

Abstract

Gilles de la Tourette syndrome (GTS) is a neuropsychiatric disorder characterized by multiple motor and vocal tics. Previous structural MRI studies have identified regional abnormalities in grey matter, especially in the basal ganglia. These findings are consistent with the assumption of alterations in cortico-striato-thalamo-cortical circuits and dopaminergic neurotransmission playing a major role in the pathophysiology of GTS. Additionally, recent imaging studies suggested an involvement of sensory-motor cortices in the pathophysiology of GTS. However, little is known about the role of white matter changes in GTS. In this study, we aimed to examine whether GTS is associated with abnormalities in white matter microstructure and whether these changes are correlated with tic severity. In a morphometric study based on diffusion tensor MRI of the whole brain, we compared brain tissue diffusion characteristics between 15 unmedicated adults with GTS without psychiatric co-morbidity and 15 healthy age- and sex-matched controls. We performed voxel-based morphometry (VBM) of regional fractional anisotropy (FA) values to identify regional differences in white matter microstructure between the groups. We also tested for a linear relation...Continue Reading

References

Feb 15, 1979·The Journal of Comparative Neurology·E G JonesJ D Coulter
May 1, 1989·Neurology·R KurlanD Hewitt
Jul 1, 1989·Journal of the American Academy of Child and Adolescent Psychiatry·J F LeckmanD J Cohen
Jan 1, 1970·Brain : a Journal of Neurology·E G Jones, T P Powell
Sep 1, 1983·Journal of Behavior Therapy and Experimental Psychiatry·J G Bullen, D R Hemsley
Jan 1, 1993·The American Journal of Psychiatry·J F LeckmanD J Cohen
May 1, 1996·American Journal of Public Health·M Aickin, H Gensler
Aug 1, 1997·Neurology·J MoriartyM M Robertson
May 29, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·C G GoetzS Leurgans
Oct 16, 1999·Neurology·S H MostofskyH S Singer
Feb 25, 2000·Brain : a Journal of Neurology·M M Robertson
Mar 21, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Y Iwamura
Aug 2, 2000·Archives of General Psychiatry·E SternR J Dolan
May 16, 2001·Archives of General Psychiatry·B S PetersonR Webster
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
May 15, 2002·Psychiatry Research·Greg Hajcak, Robert F Simons
Apr 16, 2003·Archives of General Psychiatry·Bradley S PetersonLawrence Staib
Oct 31, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T E J BehrensS M Smith
Dec 16, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Carolyn KwakJoseph Jankovic
Mar 31, 2004·Journal of the Neurological Sciences·Karen MinzerHarvey S Singer
Jul 23, 2004·Journal of Magnetic Resonance Imaging : JMRI·Yusuf A Bhagat, Christian Beaulieu
Sep 24, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Dennis A NowakMichael Orth
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Oct 30, 2004·The American Journal of Psychiatry·Kerstin J PlessenBradley S Peterson
Feb 22, 2005·Lancet Neurology·Harvey S Singer
Apr 9, 2005·Current Treatment Options in Neurology·Donald L Gilbert, Tara D Lipps
May 24, 2005·NeuroImage·Derek K JonesRobert J Howard
Aug 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·David S TuchH Diana Rosas
Sep 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Paul S A KalanithiFlora M Vaccarino
Oct 26, 2005·Neurology·Michael H BlochBradley S Peterson
Dec 14, 2005·Journal of Developmental and Behavioral Pediatrics : JDBP·Douglas W WoodsSusanna Chang
Jun 30, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marie HolzapfelAllan L Reiss

❮ Previous
Next ❯

Citations

Jan 19, 2013·Experimental Brain Research·Sarah M Kranick, Mark Hallett
May 7, 2010·Current Neurology and Neuroscience Reports·Thomas E Kimber
Oct 21, 2010·Brain : a Journal of Neurology·Yulia WorbeStéphane Lehéricy
Nov 13, 2010·Brain : a Journal of Neurology·Bogdan DraganskiRichard S Frackowiak
Mar 22, 2012·Brain : a Journal of Neurology·Yulia WorbeHabib Benali
Feb 16, 2012·BMC Neuroscience·Matthias WittfothKirsten R Müller-Vahl
Oct 13, 2012·BMC Neurology·Irene NeunerWolfram Kawohl
Jan 13, 2012·PloS One·Stephanie FranzkowiakAlfons Schnitzler
Jul 4, 2013·Journal of Psychiatry & Neuroscience : JPN·Scott A WylieWery P M van den Wildenberg
Nov 2, 2013·Brain : a Journal of Neurology·Götz ThomallaAlexander Münchau
Jul 9, 2010·Current Opinion in Neurology·Bogdan Draganski, Kailash P Bhatia
Jan 29, 2016·Parkinsonism & Related Disorders·Odette SchunkeChristos Ganos
Oct 9, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Yulia WorbeLéon Tremblay
Mar 3, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Andrea E CavannaMary M Robertson
Mar 5, 2016·Current Neurology and Neuroscience Reports·Aysegul Gunduz, Michael S Okun
Nov 17, 2009·Journal of Psychosomatic Research·Michael Orth
Nov 17, 2009·Journal of Psychosomatic Research·Kerstin J PlessenBradley S Peterson
Dec 2, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Judith BuseVeit Roessner
May 13, 2011·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Alexander MünchauVeit Roessner
Oct 7, 2015·Trends in Cognitive Sciences·Georgina M JacksonStephen R Jackson
Sep 21, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Laura AvanzinoGiovanni Abbruzzese
Mar 11, 2011·Human Brain Mapping·Veit RoessnerJürgen Baudewig
Jun 30, 2011·Developmental Neurobiology·Li-Jen Lee, Lukas Jyuhn-Hsiarn Lee
Jul 30, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Stephanie FranzkowiakAlfons Schnitzler
Oct 21, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Tobias BäumerAlexander Münchau
Jan 27, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Jennifer FinisAlexander Münchau
Mar 29, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Antonio SuppaAlfredo Berardelli
May 29, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Signe Søndergaard JeppesenLiselotte Skov
Nov 6, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Veit RoessnerGunther Helms
Jul 6, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Antonio SuppaAlfredo Berardelli
Sep 18, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Yulia WorbeAndreas Hartmann
Jul 22, 2014·Human Brain Mapping·Sule TinazSilvina G Horovitz
Jul 11, 2012·NeuroImage·Katja Biermann-RubenAlfons Schnitzler
Dec 29, 2013·NeuroImage. Clinical·Bastian ChengGötz Thomalla
Dec 15, 2012·Neuroscience and Biobehavioral Reviews·Christos GanosAlexander Münchau
Nov 22, 2014·Journal of Obsessive-compulsive and Related Disorders·Jessica A Church, Bradley L Schlaggar
Sep 8, 2009·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Cherine FahimAlan C Evans
Jan 24, 2015·Neuroscience and Biobehavioral Reviews·Aniko FarkasChristian Beste
Oct 9, 2014·Frontiers in Neurology·Pierpaolo AlongiDaniela Perani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.