PMID: 8615075Jan 1, 1995Paper

Structural changes of anterior horn neurons and their synaptic input caudal to a low thoracic spinal cord hemisection in the adult rat: a light and electron microscopic study

Acta Neuropathologica
W NacimientoG W Kreutzberg

Abstract

Structural changes in lumbosacral ventral horn neurons and their synaptic input were studied at 3, 10, 21, 42, and 90 days following low thoracic cord hemisection in adult rats by light microscopic examination of synaptophysin immunoreactivity (SYN-IR) and by electron microscopy. There was an ipsilateral transient decrease in SYN-IR at the somal and proximal dendritic surfaces of anterior horn neurons which extended caudally from the site of injury over a postoperative (p.o.) period of 42 days. Concomitantly, at 21 days p.o., perineuronal SYN-IR started to recover in upper lumbar segments. By 90 days p.o., a normal staining pattern of SYN was noted in upper and mid lumbar segments, but the perineuronal SYN-IR was still slightly below normal levels in low lumbar and sacral segments. Electron microscopy revealed ultrastructural changes coincident with the alterations in SYN-IR. At 3 days p.o., phagocytosis of degenerating axon terminals by activated microglial cells was observed at the somal and proximal dendritic surfaces of ventral horn neurons. These changes were most prominent up to two segments caudal to the lesion. At 10 days p.o., advanced stages of bouton phagocytosis were still detectable in all lumbosacral motor nuclei....Continue Reading

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Citations

Dec 6, 2005·Experimental Brain Research·Marcus OhlssonLeif A Havton
May 3, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Susana L GonzalezAlejandro F De Nicola
Dec 20, 2012·Journal of Neurotrauma·Elisa López-DoladoJorge E Collazos-Castro
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Feb 21, 2019·Neurorehabilitation and Neural Repair·Kazu KobayakawaV Reggie Edgerton
May 15, 2016·The European Journal of Neuroscience·Vedangana SainiIgor Jakovcevski
Jun 3, 2021·International Journal of Molecular Sciences·Jadwiga N BilchakMarie-Pascale Côté
Mar 26, 2009·Frontiers in Neuroendocrinology·Alejandro F De NicolaMichael Schumacher

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