Structural changes of the brain in relation to occupational stress

Cerebral Cortex
Ivanka Savic

Abstract

Despite mounting reports about the negative effects of chronic occupational stress on cognitive functions, it is still uncertain whether and how this type of stress is associated with cerebral changes. This issue was addressed in the present MRI study, in which cortical thickness (Cth) and subcortical volumes were compared between 40 subjects reporting symptoms of chronic occupational stress (38 ± 6 years) and 40 matched controls (36 ± 6 years). The degree of perceived stress was measured with Maslach Burnout Inventory. In stressed subjects, there was a significant thinning of the mesial frontal cortex. When investigating the correlation between age and Cth, the thinning effect of age was more pronounced in the stressed group in the frontal cortex. Furthermore, their amygdala volumes were bilaterally increased (P = 0.020 and P = 0.003), whereas their caudate volumes were reduced (P = 0.040), and accompanied by impaired fine motor function. The perceived stress correlated positively with the amygdala volumes (r = 0.44, P = 0.04; r = 0.43, P = 04). Occupational stress was found to be associated with cortical thinning as well as with selective changes of subcortical volumes, with behavioral correlates. The findings support the hyp...Continue Reading

References

Jan 1, 1978·Acta Psychiatrica Scandinavica. Supplementum·S MontgomeryD Montgomery
Jul 1, 1988·The Journal of Comparative Neurology·M Petrides, D N Pandya
Aug 1, 1967·Journal of Psychosomatic Research·T H Holmes, R H Rahe
Nov 30, 1994·Annals of the New York Academy of Sciences·B S McEwen
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J BengzonO Lindvall
Dec 24, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·B S McEwenC McKittrick
Apr 16, 1999·Psychosomatic Medicine·J C PruessnerC Kirschbaum
Aug 24, 1999·Journal of Psychosomatic Research·S MelamedP Froom
Mar 29, 2000·Progress in Brain Research·B S McEwen
Apr 13, 2000·The European Journal of Neuroscience·E IsovichE Fuchs
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Oct 24, 2000·Neurobiology of Disease·R M Sapolsky
Aug 2, 2001·The American Journal of Psychiatry·O BonneA Y Shalev
Sep 27, 2001·Psychosomatic Medicine·E Y DeykinK Creamer
Jul 13, 2002·Biological Psychiatry·Gerardo VillarrealWilliam M Brooks
Sep 3, 2002·Occupational and Environmental Medicine·Torbjorn AkerstedtG Kecklund
Jan 28, 2003·Nature Neuroscience·Elizabeth R SowellArthur W Toga
Mar 19, 2003·Revista latino-americana de enfermagem·Thelma S MatsukuraJorge Oishi
Jun 13, 2003·Bulletin of Experimental Biology and Medicine·B Ya RyzhavskiiT V Sokolova
Aug 30, 2003·Medical Image Analysis·F KruggelD Y von Cramon
Sep 26, 2003·Journal of Psychosomatic Research·Giorgio GrossiKristina Orth-Gomér
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benno RoozendaalJames L McGaugh
Apr 14, 2004·Basic & Clinical Pharmacology & Toxicology·Ole LadefogedHenrik Rye Lam
Sep 1, 2004·Biological Psychiatry·Ramón J L LindauerBerthold P R Gersons
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lukas PezawasDaniel R Weinberger
Nov 19, 2004·The European Journal of Neuroscience·Edmund Y H Wong, Joe Herbert
Feb 11, 2005·Cerebral Cortex·Sarah M BrownCara L Wellman
Jun 1, 2005·Biological Psychology·Agneta SandströmLars Nyberg
Sep 28, 2005·Journal of Psychosomatic Research·Giorgio GrossiKarin Holm
Dec 13, 2005·Social Psychiatry and Psychiatric Epidemiology·Kirsi AholaJouko Lönnqvist
Mar 30, 2006·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Paula M C MommersteegLorenz J P van Doornen

❮ Previous
Next ❯

Citations

Apr 22, 2014·Experimental Neurology·Ivanka Savic
Jan 11, 2017·Human Brain Mapping·Ivanka SavicAngelica Lindén Hirschberg
Jan 30, 2018·Frontiers in Human Neuroscience·Jonatan Ottino-GonzálezMaite Garolera
Sep 13, 2019·BMC Public Health·Benyam W DubaleBizu Gelaye
Dec 12, 2017·Human Brain Mapping·Amirhossein Manzouri, Ivanka Savic
Oct 28, 2018·Scientific Reports·J Ottino-GonzálezM Garolera
Jul 25, 2019·Frontiers in Psychology·Johan BertilssonMarcus Nyström
Jun 9, 2020·Stress : the International Journal on the Biology of Stress·Simon SkauH Georg Kuhn
Apr 1, 2020·Frontiers in Psychology·Ross W MayFrank D Fincham
May 23, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Jee In KangOwen M Wolkowitz
Mar 31, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Adam BayesGordon Parker
Apr 1, 2021·Journal of Neuroscience Research·Henriette AcostaTilo Kircher
Aug 11, 2021·The Psychiatric Clinics of North America·Paul H GroenewalMarissa R Norman
Sep 2, 2020·The Journal of Thoracic and Cardiovascular Surgery·Rizwan A ManjiRakesh C Arora
Aug 24, 2021·The Journal of Pain : Official Journal of the American Pain Society·Jared J TannerKimberly T Sibille
Aug 21, 2021·The European Journal of Neuroscience·Satu PakarinenKiti Müller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.