Structural characterisation and discrimination of the aerial parts of Paris polyphylla var. yunnanensis and Paris polyphylla var. chinensis by UHPLC-QTOF-MS coupled with multivariate data analysis

Phytochemical Analysis : PCA
Meng-Yuan LiangJie Yang

Abstract

As sources of Rhizoma Paridis are facing shortages, utilising the aerial parts of Paris polyphylla has emerged as a promising additional source. However, the components in the aerial parts still need to be explored, and it is difficult to distinguish the aerial parts of P. polyphylla Smith var. yunnanensis (PPY) and P. polyphylla var. chinensis (PPC), two varieties of P. polyphylla. This study aimed to establish a comprehensive platform to characterise steroid saponins from the aerial parts of PPY and PPC and to discriminate these two varieties. A dereplication approach and ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) analysis were used for the characterisation of steroidal saponins in the aerial parts of PPY and PPC. Multivariate statistical analysis was performed to differentiate these two varieties and screen discriminant variables. In addition, a genetic algorithm-optimised for support vector machines (GA-SVM) model was developed to predict P. polyphylla samples. The distribution of steroidal saponins in PPY and PPC was visualised by a heatmap. A total of 102 compounds were characterised from the aerial parts of PPY and PPC by dereplication. A clear separation of P...Continue Reading

References

Feb 19, 2003·Phytochemistry·Lloyd W SumnerRichard A Dixon
May 19, 2009·Steroids·Ting ZhangQiang Wang
Jan 24, 2012·Journal of Pharmaceutical and Biomedical Analysis·Li-ping KangBai-ping Ma
May 17, 2013·Metabolomics : Official Journal of the Metabolomic Society·Angela MariWolfram Weckwerth
Apr 4, 2015·Public Understanding of Science·Annamaria Lusardi
Jun 15, 2017·Scientific Reports·Yun SongNaizhong Chen

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Citations

Jul 15, 2020·European Journal of Drug Metabolism and Pharmacokinetics·Wei LuPan Lei
Apr 3, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Tong-Tong JinHui-Jun Li
Jun 11, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·JiaQi YueYuanZhong Wang

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