Structural characteristics and bioactive properties of a novel polysaccharide from Flammulina velutipes

Carbohydrate Polymers
Tiantian ZhangSen Lian

Abstract

A new water-soluble polysaccharide (FVP1) was extracted from Flammulina velutipes by traditional method "water extraction and alcohol precipitation" and purified by column chromatography. Physicochemical characterization showed that FVP1 was a homogeneous polysaccharide with a relative molecular weight of 54.78 kDa. It is composed of mannose (7.74%), glucose (70.41%), and galactose (16.38%). FVP1 (1000 mg/mL) possessed significant immune activity by increasing the secretion of nitric oxide (NO), tumour necrosis factor-α (TNF-α) (3183 ± 133.84 pg/mL), interleukin (IL)-6 (1133.21 ± 39.05 pg/mL), and IL-12 (579.96 ± 74.53 pg/mL) in macrophages. Furthermore, FVP1 showed significant hepatitis B surface antibody (anti-HBV) activity through reducing the expression of hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA replication. These results suggest a novel role for FVP1 to be applied as an immunomodulators in dietary supplements to prevent HBV infection.

Citations

Jan 20, 2021·International Journal of Biological Macromolecules·Prasenjit MaityGajendra Nath Maity
Nov 25, 2019·International Journal of Biological Macromolecules·Tingting SunLinjuan Huang
Apr 23, 2021·International Journal of Biological Macromolecules·Zelalai SimayiNigary Yadikar
Mar 8, 2019·International Journal of Biological Macromolecules·Parhat RoziAbulimiti Yili

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