Structural characteristics of neurons and macrogliocytes in interconnected regions of the mesoaccumbocingulate dopaminergic system in rats.

Neuroscience and Behavioral Physiology
A V Droblenkov, N R Karelina

Abstract

Studies in rats (n = 6) in normal conditions addressed the morphometric parameters of neurons and macrogliocytes in the interconnected anteromedial regions of the mesoaccumbocingulate (MAC) dopaminergic system, which is important for diagnosing and identifying the morphogenesis of addiction states. A spatial model of the system was constructed which took into account the mean distance of frontal sections from the frontal pole; the densities of neurons and macrogliocytes were assessed in the central part of the paranigral nucleus of the ventral tegmental area (VTA) and the compact zone of the substantia nigra (SN) and in the interconnected anteromedial segments of these midbrain nuclei, the cingulate fields, the nucleus accumbens (NA), and layer VI of the pregenual (Cg3) and layer III of the supragenual (Cg2) cingulate fields. The anteromedial segments of the paranigral nucleus of the VTA and the compact zone of the SN, which are interconnected with these cingulate structures and the NA, contained larger numbers of neurons than the other segments, as they occupied a larger volume, while there were no differences in the volumes of neurons in the anterior and central parts of these segments. The anterior part of the compact zone o...Continue Reading

References

May 1, 1987·Brain Research·R D Oades, G M Halliday
Jan 1, 1967·Progress in Nucleic Acid Research and Molecular Biology·H Hydén
Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Aug 19, 1983·Science·N E Goeders, J E Smith
Feb 1, 1995·Brain : a Journal of Neurology·O DevinskyB A Vogt
Apr 1, 1993·Alcoholism, Clinical and Experimental Research·J G ModellJ Y Lee
Mar 28, 2001·The American Journal of the Medical Sciences·D H Streeten
Mar 6, 2002·The American Journal of the Medical Sciences·W Dietz
Apr 15, 2004·Current Opinion in Neurobiology·Venkata S Mattay, Terry E Goldberg
Apr 9, 2005·Journal of Microscopy·J C Fiala
May 19, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Virginia L LucaitesDavid L Nelson
Sep 20, 2005·Experimental Brain Research·Igor RiecanskýKlaus-Peter Hoffmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.