Structural characterization and DPPH radical scavenging activity of an arabinoglucogalactan from Panax notoginseng root

Journal of Natural Products
Yalin Wu, Denong Wang

Abstract

The structure of an antiradical arabinoglucogalactan ( 1) from Panax notoginseng roots was determined. This polymeric carbohydrate was obtained through successive phosphate buffer (pH 7.0) extraction after cold-water pretreatment and purification by ion-exchange and gel-filtration chromatography. Monosaccharide analysis, permethylation analysis, NaIO 4 and CrO 3 oxidations, Smith degradation, graded acid hydrolysis, and IR and NMR experiments indicated that 1 possesses a backbone of (1-->3)-linked beta- d-galactofuranosyl residues, with branches of alpha- l-Ara f-(1-->4)-beta- d-Glc p-(1--> residues at O-6. Additionally, 1 exhibited high scavenging activity against DPPH free radicals with a 50% scavenging concentration (SC50) of 11.72 +/- 0.91 microg/mL, suggesting that this arabinoglucogalactan is a potential antiradical.

Citations

Aug 4, 2015·International Journal of Biological Macromolecules·Shiling FengChunbang Ding
Apr 26, 2016·The American Journal of Chinese Medicine·Rui JiaoKwok Fai So
Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Christophe E RedonOlga A Sedelnikova
Jan 24, 2015·International Journal of Biological Macromolecules·Sujay Kumar MajeeBimalendu Ray
Oct 11, 2017·International Journal of Biological Macromolecules·Shian ShenChunbang Ding
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hongyu QiXiangyan Li

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