Structural Characterization and Evaluation of the Antioxidant Activity of Phenolic Compounds from Astragalus taipaishanensis and Their Structure-Activity Relationship

Scientific Reports
Wenjun PuDan Zhou

Abstract

Eight phenolic compounds were isolated using bio-guided isolation and purified from the roots of Astragalus taipaishanensis Y. C. Ho et S. B. Ho (A. taipaishanensis) for the first time. Their structures were elucidated by ESI-MS, HR-ESI-MS, 1D-NMR and 2D-NMR as 7,2'-dihydroxy-3',4'-dimethoxy isoflavan (1), formononetin (2), isoliquiritigenin (3), quercetin (4), kaempferol (5), ononin (6), p-hydroxybenzoic acid (7) and vanillic acid (8). Six flavonoids (compounds 1-6) exhibited stronger antioxidant activities (determined by DPPH, ABTS, FRAP and lipid peroxidation inhibition assays) than those of BHA and TBHQ and also demonstrated noticeable protective effects (particularly quercetin and kaempferol) on Escherichia coli under oxidative stress. Additionally, the chemical constituents compared with those of Astragalus membranaceus and the structure-activity relationship of the isolated compounds were both analyzed. The results clearly demonstrated that A. taipaishanensis has the potential to be selected as an alternative medicinal and food plant that can be utilized in health food products, functional tea and pharmaceutical products.

References

Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Jun 21, 2001·Journal of Agricultural and Food Chemistry·S Burda, W Oleszek
Aug 9, 2002·Journal of Agricultural and Food Chemistry·Xia Q MaKarl W K Tsim
Dec 24, 2002·Cancer Chemotherapy and Pharmacology·Rutao CuiHong Shen
Jul 14, 2004·Biochemical and Biophysical Research Communications·Bao-Mei ShaoXiao-Ming Gao
Aug 22, 2006·Phytochemistry·Ameha SeyoumFathy Kandeel El-Fiky
Sep 19, 2008·Journal of Agricultural and Food Chemistry·Xiangjiu HeRui Hai Liu
Jan 13, 2009·Free Radical Biology & Medicine·Galina V SmirnovaOleg N Oktyabrsky
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Kanti Bhooshan Pandey, Syed Ibrahim Rizvi
Apr 19, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong-Mei WangShan-Shan Wang
Oct 9, 2013·BMC Complementary and Alternative Medicine·Priyanka DharShashi Bala Singh
Jan 23, 2014·Journal of Food Science·Luis Alberto Ortega-RamirezJesus Fernando Ayala-Zavala
Sep 24, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrei MocanIoan Tilea

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Citations

Nov 22, 2016·Journal of the Science of Food and Agriculture·Suprama DattaUday S Annapure
Feb 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Siti Sarwani Putri Mohamed IsaJamaludin Mohamad
Dec 17, 2020·Phytotherapy Research : PTR·Bahare SalehiCarmen Sadaka
Aug 18, 2021·Journal of Cellular and Molecular Medicine·Zhixiao LuoYan Lei

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Methods Mentioned

BETA
NMR
ABTS

Software Mentioned

SPSS ( Statistical Package for the Social Sciences )

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