Structural Characterization and Immunomodulatory Activity of a Novel Polysaccharide from Lepidium meyenii

Journal of Agricultural and Food Chemistry
Mengmeng ZhangHui Wu

Abstract

A novel polysaccharide named as MC-1 was isolated from the roots of Lepidium meyenii using a water extraction method. Structural characterization revealed that MC-1 had an average molecular weight of 11.3 kDa and consisted of arabinose (26.21%), mannose (11.81%), glucose (53.66%), and galactose (8.32%). The main linkage types of MC-1 were proven to be (1 → 5)-α-L-Ara, (1 → 3)-α-L-Man, (1 → 2,6)-α-L-Man, (1 → )-α-D-Glc, (1 → 4)-α-D-Glc, (1 → 6)-α-D-Glc and (1 → 6)-β-D-Gal by methylation analysis, periodate oxidation-Smith degradation and NMR analysis. The immunostimulating assay indicated that MC-1 could significantly enhance the pinocytic and phagocytic capacity and promote the NO, TNF-α, and IL-6 secretion of RAW 264.7 cells, involving toll-like receptor 2, complement receptor 3, and mannose receptor mainly. These results suggested the potential utilization of MC-1 as an attractive functional food supplement candidate for hypoimmunity population.

References

Jan 5, 2002·Phytochemistry·Ilias MuhammadIkhlas A Khan
Jun 13, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Subhra K Biswas, Ajit Sodhi
Sep 19, 2002·Journal of Agricultural and Food Chemistry·Sonia PiacenteCosimo Pizza
Apr 30, 2003·The Journal of Experimental Medicine·Benjamin N GantnerDavid M Underhill
Aug 23, 2003·Journal of Natural Products·Baoliang CuiQun Yi Zheng
Feb 3, 2005·Journal of Agricultural and Food Chemistry·Jianping ZhaoIkhlas A Khan
Nov 9, 2005·International Immunopharmacology·Igor A SchepetkinMark T Quinn
Jan 24, 2006·International Immunopharmacology·Igor A Schepetkin, Mark T Quinn
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Julio RubioGustavo F Gonzales
Jan 27, 2009·Chemical Society Reviews·Anna CarlmarkMichael Malkoch
Jun 6, 2009·Journal of Microbiology and Biotechnology·Hee Hwan LeeEock Kee Hong
Mar 2, 2012·The Journal of Clinical Investigation·Antonio Sica, Alberto Mantovani
Apr 18, 2012·Carbohydrate Research·Rodrigo Tinoco FigueiredoEliana Barreto-Bergter
Sep 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yu-Hsiang KuanYu-Chao Chang
Oct 31, 2012·Journal of Agricultural and Food Chemistry·Xiaofei XuXuewu Zhang
Feb 23, 2013·Critical Reviews in Immunology·Charles D Mills
Dec 18, 2013·Journal of Ethnopharmacology·Fumiaki UchiyamaMisato Ogata
Jun 17, 2014·Climacteric : the Journal of the International Menopause Society·L StojanovskaC Haines
Oct 15, 2014·Asian Pacific Journal of Tropical Medicine·Juana Del Valle MendozaLuis J Del Valle
Feb 11, 2015·Journal of Agricultural and Food Chemistry·Naisheng BaiMin-Hsiung Pan
Aug 11, 2015·Carbohydrate Polymers·Sónia S FerreiraManuel A Coimbra

❮ Previous
Next ❯

Citations

Dec 10, 2016·Journal of Agricultural and Food Chemistry·Wen-Juan LiMing-Yong Xie
Jun 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Erna LiDaorui Pang
Jun 28, 2019·International Journal of Biological Macromolecules·Yao WenRongmin Yu
Dec 15, 2020·International Journal of Biological Macromolecules·Shaojie ZhangYuanqiang Guo
Jan 29, 2021·International Journal of Biological Macromolecules·Zeineb Mzoughi, Hatem Majdoub
Nov 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shuang SunZhenya Zhang
Oct 19, 2020·International Journal of Biological Macromolecules·Yun-Tao WuTao Zhou
Apr 21, 2021·International Journal of Biological Macromolecules·Yao WenRongmin Yu
Jun 11, 2021·Carbohydrate Research·Cheng-Yang FuWei Cao
Aug 15, 2021·International Journal of Biological Macromolecules·Linlin HuangQuanhong Li
Jan 20, 2018·Journal of Agricultural and Food Chemistry·Liyuan YunMin Zhang
Sep 4, 2021·International Journal of Biological Macromolecules·Xuyu ZhangYixi Bao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.