Structural characterization and in vitro antioxidant activity of kojic dipalmitate loaded w/o/w multiple emulsions intended for skin disorders

BioMed Research International
M L GonçalezM Chorilli

Abstract

Multiple emulsions (MEs) are intensively being studied for drug delivery due to their ability to load and increase the bioavailability of active lipophilic antioxidant, such as kojic dipalmitate (KDP). The aim of this study was to structurally characterize developed MEs by determining the average droplet size (Dnm) and zeta potential (ZP), performing macroscopic and microscopic analysis and analyzing their rheological behavior and in vitro bioadhesion. Furthermore, the in vitro safety profile and antioxidant activity of KDP-loaded MEs were evaluated. The developed MEs showed a Dnm of approximately 1 micrometer and a ZP of -13 mV, and no change was observed in Dnm or ZP of the system with the addition of KDP. KDP-unloaded MEs exhibited ''shear thinning" flow behavior whereas KDP-loaded MEs exhibited Newtonian behavior, which are both characteristic of antithixotropic materials. MEs have bioadhesion properties that were not influenced by the incorporation of KDP. The results showed that the incorporation of KDP into MEs improved the safety profile of the drug. The in vitro antioxidant activity assay suggested that MEs presented a higher capacity for maintaining the antioxidant activity of KDP. ME-based systems may be a promising ...Continue Reading

References

Feb 15, 2000·Biophysical Chemistry·S V MalheirosE de Paula
Jun 19, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Cinthia Fernanda ZanattaMaría Pilar Vinardell
Aug 25, 2009·Bioorganic & Medicinal Chemistry Letters·Jin-Mi NohYoon-Sik Lee
May 11, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wasfy M ObeidatCornelia M Keck
Feb 12, 2011·International Journal of Pharmaceutics·Judith KuntscheHeike Bunjes
Oct 18, 2011·Journal of the American Academy of Dermatology·Caterina LongoGiovanni Pellacani
Dec 12, 2012·Drug Development and Industrial Pharmacy·Flávia Chiva CarvalhoMarlus Chorilli
Feb 2, 2013·Facial Plastic Surgery Clinics of North America·Marty O VisscherW John Kitzmiller
Apr 3, 2013·Annales de dermatologie et de vénéréologie·M Rendon, S Horwitz
Mar 7, 2014·International Journal of Nanomedicine·Gisela Bevilacqua Rolfsen Ferreira da SilvaAnselmo Gomes de Oliveira
Mar 22, 2014·Pathologie-biologie·J Labat-Robert, L Robert
Apr 16, 2014·Journal of Nanoscience and Nanotechnology·Werner F Schmidt, Surya Singh
May 16, 2015·Pharmaceutical Development and Technology·Giovana CalixtoMarlus Chorilli
Sep 4, 2015·Journal of Nanoscience and Nanotechnology·Márcia Helena OyafusoMarlus Chorilli

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Citations

Dec 30, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jéssica BernegossiMarlus Chorilli
Feb 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giovana Maria Fioramonti CalixtoMarlus Chorilli
May 20, 2016·International Journal of Molecular Sciences·Patricia B da SilvaMarlus Chorilli
Apr 7, 2019·Molecular Diversity·Vesna Petrović PerokovićSrđanka Tomić
Jul 24, 2021·Nanotechnology·Min Hyeong SonYun Kyung Jung

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