Structural characterization and quantitation of compound loading of disubstituted benzoates bound to Wang resin through high-resolution magic angle spinning NMR spectroscopy

Magnetic Resonance in Chemistry : MRC
Jesús BlasJuan F Espinosa

Abstract

The combination of 1D and 2D high-resolution magic angle spinning NMR experiments led to the assignment of the proton and carbon resonances for several disubstituted benzoates bound to a polystyrene resin through a Wang linker. It is shown that the signal corresponding to the methylene protons of the linker can be utilized to monitor the solid-phase reactions and determine the loading of the compounds on the resin.

References

Jan 10, 2001·Journal of Combinatorial Chemistry·R HanyD Obrecht
Apr 5, 2001·Biotechnology and Bioengineering·Y R de Miguel, A S Shearer
Apr 5, 2001·Biotechnology and Bioengineering·M J Shapiro, J S Gounarides
Apr 13, 2001·Journal of Combinatorial Chemistry·J M SalvinoR Labaudiniere
Jul 27, 2001·Combinatorial Chemistry & High Throughput Screening·G LippensG Chessari
Jul 27, 2001·Combinatorial Chemistry & High Throughput Screening·C EnjalbalJ L Aubagnac

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Citations

Jan 23, 2016·Magnetic Resonance in Chemistry : MRC·Fredrik Elwinger, István Furó
Jun 9, 2015·Magnetic Resonance in Chemistry : MRC·Fredrik ElwingerIstván Furó

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