Abstract
A series of highly purified galacturonate polysaccharides have been extracted from the Aloe vera plant and analyzed in terms of chemical composition and molecular weight. This Aloe vera polysaccharide (AvP) has been found to exist as a high molecular weight species and possess a unique chemical composition, including a high galacturonic acid (GalA) content and low degree of methyl ester substitution. These factors facilitate gel formation upon exposure to low concentrations of calcium ions, leading to potential application in formulations designed for in situ nasal or subcutaneous protein delivery. Thorough examination of classic dilute solution properties, the [eta]-M(w), and R(g)-M(w) relationships, persistence length (L(p)), and inherent chain stiffness (B parameter), indicate an expanded random coil in aqueous salt solutions. The critical concentration for transition from dilute to concentrated solution, C(e), was determined by measuring both the zero shear viscosity (eta(o)) and fluorescence emission of the probe molecule 1,8-anilino-1-naphthalene sulfonic acid (1,8-ANS) as a function of polymer concentration. Examination of zeta potential and C(e) as a function of ionic strength indicates that the shift in C(e) from 0.60 ...Continue Reading
References
Apr 1, 1992·Archives of Biochemistry and Biophysics·M L FishmanR Scorza
Apr 1, 1991·International Journal of Biological Macromolecules·M A Axelos, J F Thibault
Jun 1, 1989·International Journal of Biological Macromolecules·M A AxelosJ Lefebvre
Jan 1, 1974·Macromolecules·H Yamakawa, M Fujii
Jan 1, 1971·Biopolymers·O Smidsrod, A Haug
Mar 15, 1982·Journal of Molecular Biology·D A PowellD A Rees
Sep 1, 1996·Biopolymers·S CrosS Pérez
Apr 17, 1999·International Journal of Pharmaceutics·R J SoaneL Illum
Jun 22, 2000·Biopolymers·M HigashimuraG W Robijn
Aug 23, 2001·Advanced Drug Delivery Reviews·L IllumS S Davis
Jan 5, 2002·Biomacromolecules·I Braccini, S Pérez
May 15, 2002·Biomacromolecules·Yu ChengRobert K Prud'homme
Jan 28, 2003·Drug Discovery Today·Lisbeth Illum
Feb 28, 2003·Analytical Biochemistry·M BertschR J Kassner
Mar 6, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lisbeth Illum
Mar 20, 2003·Carbohydrate Research·Christoph RosenbohmNiallW G Young
May 24, 2003·Biomaterials·LinShu LiuKevin B Hicks
Nov 11, 2003·Biomacromolecules·Raniero MendichiAlberto Giacometti Schieroni
Jan 22, 2004·Biochemical and Biophysical Research Communications·Partha HazraNilmoni Sarkar
Mar 9, 2004·Biomacromolecules·Marshall L FishmanDavid R Coffin
Apr 15, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·James BlanchetteNicholas A Peppas
May 10, 2005·The European Physical Journal. E, Soft Matter·P KujawaF M Winnik
Sep 13, 2005·Biomacromolecules·R NotoP L San Biagio
Oct 29, 2005·Drug Delivery·Yong-Hong LiaoMarc B Brown
Nov 15, 2005·Biomacromolecules·François CapelVirginie Langendorff
Jan 10, 2006·Biomacromolecules·Caroline LöfgrenAnne-Marie Hermansson
Mar 31, 2006·The New England Journal of Medicine·John J TreanorMark Wolff
Jul 11, 2006·Biomacromolecules·Inger Mari Nygård VoldBjørn E Christensen
Jan 9, 2007·Biomacromolecules·Fabrice AvaltroniKevin J Wilkinson
Citations
Apr 7, 2009·Journal of Materials Science. Materials in Medicine·Henry T Peng, Pang N Shek
Mar 20, 2010·Critical Reviews in Food Science and Nutrition·Elena Rodríguez RodríguezCarlos Díaz Romero
Nov 14, 2015·Drug Discovery Today·Christina Karavasili, Dimitrios G Fatouros
May 26, 2009·Carbohydrate Research·Yongbo SongLina Zhang
Dec 18, 2008·Macromolecular Bioscience·Yuko OgushiKoei Kawakami
Sep 27, 2014·Carbohydrate Polymers·Jiachang Huang, Li Zhou
Aug 19, 2014·Carbohydrate Polymers·Atiga AbodinarGordon A Morris
Aug 16, 2016·Carbohydrate Polymers·Xiaoqi XuJun Wang
Aug 16, 2016·Carbohydrate Polymers·Xiaoqi XuKunhao Jiang
Oct 13, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vinicius B V MacielTelma T Franco
Oct 22, 2008·Biomacromolecules·Shawn D McConaughyCharles L McCormick
Aug 20, 2018·International Journal of Biological Macromolecules·Kiran PatruniSrinivasa Rao Pavuluri
Oct 30, 2010·Biomacromolecules·Liqun YangHui Liu
Aug 15, 2021·International Journal of Biological Macromolecules·Yuheng TaoQiang Yong