PMID: 2492056Feb 1, 1989Paper

Structural characterization of antiidiotypic antibodies. Evidence that Ab2s are derived from the germline differently than Ab1s

The Journal of Experimental Medicine
K MeekJ D Capra

Abstract

We have found that syngeneic Ab2s in the antiarsonate system are serologically and structurally similar to one another. In contrast, the allogeneic Ab2 response is heterogeneous and derives from a large number of unrelated germline gene segments. The Ab2 response of the BALB/c strain to polyclonal A/J Ars A molecules can probably best be compared with a response to a foreign protein and might have been predicted in a strain that completely lacks the H chain V region gene from which the Ab1 derives. Partial variable region sequences of Ab2s from three other systems in addition to previously reported Ab2 structures indicates that this difference in allogeneic vs. syngeneic Ab2s may be a general phenomena. These data support Jerne's hypothesis of complementary V region genes existing in the germline. However, there is good evidence that these antiidiotypic antibodies are not derived directly from the germline, as somatic processes most likely play an important role in their generation. The D segments of Ab2s in the arsonate system as well as in other systems, are novel in structure and cannot easily be explained by previously described germline D segments. D-D fusion may play a role in the generation of the third hypervariable reg...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C BruckM I Greene
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J SharonM Ptashne
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·I Sanz, J D Capra
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K MeekJ D Capra
Jan 1, 1988·Molecular Immunology·H L ChengH Kohler
Aug 5, 1988·Journal of Molecular Biology·G A RathbunP W Tucker
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·F W Alt, D Baltimore
Jun 1, 1984·Immunological Reviews·N K Jerne
Jan 1, 1982·The Journal of Experimental Medicine·Y Kurosawa, S Tonegawa

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Citations

Jul 1, 1992·Molecular Immunology·Y J DengF Karush
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J TassignonK Meek
Jan 1, 1990·The Journal of Experimental Medicine·M ShlomchikM Weigert
Nov 1, 1990·The Journal of Experimental Medicine·A J Feeney
Aug 1, 1992·Immunological Reviews·T N MarionR J Hill
Sep 1, 1991·European Journal of Immunology·T KoizumiR S Schwartz
Nov 1, 1992·European Journal of Immunology·E A ArmandolaS Ferrone
Jan 1, 1992·International Reviews of Immunology·L VanDyk, K Meek
Apr 11, 1991·Clinical Immunology and Immunopathology·F SilvestrisR C Williams

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