PMID: 2490549Jan 1, 1989Paper

Structural characterization of cisplatin analogues by fast atom bombardment (FAB) and laser microprobe mass spectrometry (LAMMA)

Journal of Pharmaceutical and Biomedical Analysis
J ClaereboudtM Claeys

Abstract

The present study is concerned with the investigation of the potentials and limitations of fast atom bombardment (FAB) and laser microprobe mass spectrometry (LAMMA) for the structural characterization of a series of cisplatin analogues. The limiting factors for obtaining good quality FAB spectra are the solubility and the stability of the organometallic platinum complexes in the FAB matrix. In the case of a suitable matrix being found, molecular weight information is derived from the (M + H)+ and/or (M - H)- ions. Drawbacks of the application of FAB are (i) the low signal intensities of the molecular ion-like species as compared to the matrix signals and (ii) the scarcity of fragmentation necessary for structure determination. Combination of FAB with tandem mass spectrometry was used to overcome these problems. LAMMA provides a valuable alternative for the direct mass spectral analysis of cisplatin analogues. For some compounds, LAMMA results in useful mass spectra, whereas FAB fails. The abundant fragmentation yields structural information which is complementary for positive and negative ions. The laser power density applied to the sample is of critical importance for the quality of the spectra.

Citations

Feb 10, 2009·Journal of the American Society for Mass Spectrometry·Adrien NyakasStefan Schürch
Nov 1, 1991·Biological Mass Spectrometry·G K PoonS Lewis
Jul 8, 2003·Rapid Communications in Mass Spectrometry : RCM·Meng Cui, Zoltán Mester
Apr 13, 2011·Metallomics : Integrated Biometal Science·Marijana Petković, Tina Kamčeva
Sep 28, 2004·Inorganic Chemistry·Helen T ChifotidesDavid H Russell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.