Structural Characterization of Glaucoma Patients with Low Ocular Blood Flow.

Current Eye Research
Kazuko OmodakaToru Nakazawa

Abstract

Purpose: There is an unclear relationship between ocular blood flow (OBF) and the structural characteristics of the optic nerve head (ONH) in glaucoma, a multifactorial disease. This study used laser speckle flowgraphy (LSFG) to identify low-OBF glaucoma patients and investigated the ONH in these patients. Materials and Methods: In 533 eyes with glaucoma, we determined confounding factors for LSFG-measured OBF (tissue-area mean blur rate: MT) and corrected MT with a linear mixed-effects model (LMM). Structural ONH data (from fundus stereo photography), OCT data, and clinical characteristics were then compared in patients with corrected MT in the upper and lower quartiles using the LMM. Results: Single regression showed significant correlations between MT and age, spherical equivalent (SE), central corneal thickness (CCT), and a weighted count of retinal ganglion cells (wRGC), but not axial length or systemic blood pressure. Gender also significantly influenced MT; MT was corrected for these correlated factors and also glaucoma type with the LMM. The lower-quartile MT group had a significantly larger cup area and cup-disc area ratio and lower temporal quadrant circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and mac...Continue Reading

References

Sep 1, 1976·American Journal of Ophthalmology·M F LiebermanW R Green
Dec 1, 1969·Archives of Ophthalmology·D R Anderson
Apr 1, 1996·Ophthalmology·M T Nicolela, S M Drance
Jul 11, 2006·Ophthalmology·Yasuyuki SuzukiUNKNOWN Tajimi Study Group
Sep 12, 2006·Progress in Retinal and Eye Research·Gülgün Tezel
Feb 26, 2009·Current Opinion in Ophthalmology·M Cristina Leske
Apr 20, 2010·American Journal of Ophthalmology·Joseph CaprioliUNKNOWN Blood Flow in Glaucoma Discussion
Jun 21, 2011·Ophthalmology·Michael W MarcusNomdo M Jansonius
Dec 14, 2011·Progress in Retinal and Eye Research·Mohammadali AlmasiehAdriana Di Polo
Jun 19, 2013·Survey of Ophthalmology·Rupali VohraMiriam Kolko
Oct 17, 2013·Investigative Ophthalmology & Visual Science·Yukihiro ShigaToru Nakazawa
May 16, 2014·JAMA : the Journal of the American Medical Association·Robert N WeinrebFelipe A Medeiros
May 20, 2014·Survey of Ophthalmology·Hyun-Kyung Cho, Changwon Kee
Apr 11, 2015·Japanese Journal of Ophthalmology·Kazuko OmodakaToru Nakazawa
Feb 18, 2016·Asia-Pacific Journal of Ophthalmology·Toru Nakazawa
Nov 30, 2016·Asia-Pacific Journal of Ophthalmology·Pei-Chang WuChueh-Tan Chen
Feb 16, 2018·Eye·Graham W Belovay, Ivan Goldberg
Dec 24, 2018·American Journal of Ophthalmology·Ji Min KwonMin Hee Suh
Jan 16, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Stephanie WeyL Jay Katz

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