Structural characterization of lipidic systems under nonequilibrium conditions.

European Biophysics Journal : EBJ
Anan Yaghmur, Michael Rappolt

Abstract

This review covers recent studies on the characterization of the dynamics of lipidic nanostructures formed via self-assembly processes. The focus is placed on two main topics: First, an overview of advanced experimental small-angle X-ray scattering (SAXS) setups combined with various sample manipulation techniques including, for instance, stop-flow mixing or rapid temperature-jump perturbation is given. Second, our recent synchrotron SAXS findings on the dynamic structural response of gold nanoparticle-loaded vesicles upon exposure to an ultraviolet light source, the impact of rapidly mixing negatively charged vesicles with calcium ions, and in situ hydration-induced formation of inverted-type liquid-crystalline phases loaded with the local anesthetic bupivacaine are summarized. These in situ time-resolved experiments allow real-time monitoring of the dynamics of the structural changes and the possible formation of intermediate states in the millisecond to second range. The need for investigating self-assembled systems, mainly stimuli-responsive drug nanocarriers, under nonequilibrium conditions is discussed. For pharmaceutically relevant applications, it is essential to combine these investigations with appropriate in vitro an...Continue Reading

References

Mar 1, 1991·Chemistry and Physics of Lipids·P Laggner, M Kriechbaum
Nov 5, 1997·Current Opinion in Structural Biology·V Luzzati
Oct 26, 2002·Physical Review Letters·L PorcarGregory G Warr
Feb 13, 2004·Journal of Synchrotron Radiation·Andre OrthenUlrich Werthenbach
May 4, 2004·Ultrasound in Medicine & Biology·Cheri X DengJianmin Cui
Jul 21, 2004·Journal of Synchrotron Radiation·H AmenitschS Bernstorff
Jan 12, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Anan YaghmurOtto Glatter
Feb 9, 2005·Physical Review Letters·T M WeissW I Helsby
Apr 20, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Angelina AngelovaClaudie Bourgaux
Jul 1, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Liliana de CampoOtto Glatter
Aug 11, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Adam M SquiresS Finet
Apr 12, 2006·Physical Review Letters·Charlotte E ConnRichard H Templer
Jun 17, 2006·Pharmaceutical Research·Patrick Couvreur, Christine Vauthier
Aug 30, 2006·Advances in Colloid and Interface Science·P PanineT Narayanan
Nov 9, 2006·Physical Chemistry Chemical Physics : PCCP·Thomas Kaasgaard, Calum J Drummond
Jul 14, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lauri PaasonenArto Urtti
Oct 13, 2007·Journal of the American Chemical Society·Borislav AngelovPatrick Couvreur
Jun 12, 2008·Journal of the American Chemical Society·Guohui WuJoseph A Zasadzinski
Sep 23, 2008·Advances in Colloid and Interface Science·Anan Yaghmur, Otto Glatter
Dec 31, 2008·PloS One·Ruth PrasslPeter Laggner
Apr 1, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wye-Khay FongBen J Boyd
Jul 2, 2009·Lab on a Chip·Benedetta MarmiroliHeinz Amenitsch
Aug 18, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Anan YaghmurMichael Rappolt
Aug 27, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Borislav AngelovPatrick Couvreur
Mar 20, 2010·ACS Nano·Dissaya PornpattananangkulLiangfang Zhang
Apr 3, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Wye-Khay FongBen J Boyd
Apr 7, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Yao-Da DongBen J Boyd
Jul 14, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lauri PaasonenMarjo Yliperttula
Nov 5, 2010·Physical Chemistry Chemical Physics : PCCP·Anan YaghmurMichael Rappolt
Nov 17, 2010·Physical Chemistry Chemical Physics : PCCP·Borislav AngelovJan Skov Pedersen
Dec 22, 2010·Chemistry and Physics of Lipids·Nicholas J BrooksJohn M Seddon
Apr 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tri-Hung NguyenBen J Boyd
May 10, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·C V TeixeiraV Alfredsson
Jun 15, 2011·Expert Opinion on Drug Delivery·Matthew R Preiss, Geoffrey D Bothun
Jul 27, 2011·Accounts of Chemical Research·Yoshihisa NamikiMasaru Nakagawa
Aug 10, 2011·Journal of the American Chemical Society·Annela M SeddonAdam M Squires
Oct 14, 2011·ACS Nano·S Moein MoghimiRobert Langer
Jan 18, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Anan YaghmurSusan Weng Larsen

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Citations

Feb 26, 2013·International Journal of Molecular Sciences·Aljaž VelikonjaAleš Iglič
Jul 28, 2013·International Journal of Molecular Sciences·Aljaž VelikonjaAleš Iglič
Dec 7, 2013·Chemistry and Physics of Lipids·Poornima Budime SanthoshNataša Poklar Ulrih
Dec 15, 2015·Therapeutic Delivery·Intan D M AzmiAnan Yaghmur
Dec 6, 2014·International Journal of Pharmaceutics·Spomenka Milak, Andreas Zimmer
Feb 12, 2020·Materials·Theyencheri Narayanan, Oleg Konovalov
Jan 4, 2017·The Review of Scientific Instruments·Johannes MöllerTheyencheri Narayanan
May 18, 2021·Acta Pharmaceutica Sinica. B·Anan Yaghmur, Huiling Mu
Jul 6, 2020·Chemistry and Physics of Lipids·Catherine CheuMu-Ping Nieh
Jun 6, 2013·The Journal of Physical Chemistry Letters·Borislav AngelovSylviane Lesieur
Jun 2, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Sonja JosephHeike Bunjes
Jun 4, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Simone AleandriEhud M Landau

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